The luteinizing hormone-releasing hormone (LHRH) agonist ICI 118630 was found to increase testosterone production in purified rat testis Leydig cells in a concentration- and time-dependent manner, but no consistent changes in cyclic AMP levels were detectable. The stimulation of steroidogenesis by LHRH agonist was found to be dependent on the concentration of Ca2+ in the incubation medium; at l...

1 Soules MR, McCarty KS. Leiomyomas: steroid receptor content. Am J Obstet Gynecol 1982;143:6-11. 2 Fraser HM. New prospects for luteinising hormone releasing hormone as a contraceptive and therapeutic agent. Br MedJe 1982;285:990-1. 3 Sutherland IA, White S, Chambers GR, et al. A miniature infuser for the pulsatile administration of LHRH. J Biomed Eng 1984;6:129-33. 4 Chong AP, Baggish MS. Man...

Small cell carcinoma (SCC) or microcytic carcinoma of the urinary bladder is a rare entity comprising approximately 0.5% of all bladder tumors. Due to its rarity, no prospective studies evaluating the most effective treatment have been published in the medical literature. Several cases of bladder SCC have been presented so far. We describe our case report and we revise the recent literature. Ou...

To assess changes of gonad development and sex steroids hormones of R. frisii kutum, broodfish were captured during spawning season 2010 (March-April) and induced intramuscularly with following hormone treatments: single injections of 1 μg kg b.w. LHRH-A2, combination of LHRH-A2 with two dopamine antagonists as follows: 1 μg kg b.w. LHRH-A2 + 5 mg kg-1 b.w. PIM, 1 μg kg b.w. LHRH-A2 + 2.5 mg kg...

A male patient with hypogonadotropic hypogonadism has been treated by pulsatile administration lf luteinizing hormone-releasing hormone (LHRH) (20-25 micrograms, every 2 hours, sc) for 4 years 6 months. His plasma testosterone (T) concentration began to increase after 4 weeks of treatment and reached the normal range in week 5. He showed complete secondary sexual development after 1 year of tre...

Oral delivery of peptide and protein drugs has potential advantages for the aquaculture industry. The bioavailability of proteins and peptides from the intestinal tract is very low. This can be attributed in part to the proteolytic activities of the intestine. Bovine serum albumin (BSA), human (hLHRH) and salmon (sLHRH) luteinizing-hormone releasing hormones were used to evaluate the proteolyti...

BACKGROUND Oncological results of radiotherapy for locally advanced prostate cancer (PC) are significantly improved by simultaneous application of LHRH analoga (e.g. goserelin). As 85% of PC express LHRH receptors, we investigated the interaction of goserelin incubation with radiotherapy under androgen-deprived conditions in vitro. METHODS LNCaP and PC-3 cells were stained for LHRH receptors....

Analogues of luteinising hormone-releasing hormone (LHRH) are very much in fashion. Their design is clever and they offer an effective medical alternative to surgical castra-tion in the treatment of breast and prostatic cancer. In breast cancer their use in metastatic disease is increasing steadily, and current enthusiasm is such that multicentre adjuvant therapy trials in early disease are alr...