a high dose (6 mg/kg) of lidocaine, and blood lidocaine levels were measured over a 4-hour study period. Intradeltoid injection produced higher blood lidocaine levels and more rapid development of peak blood levels than did intragluteal injection. Administration of high-dose lidocaine (average dose 450 mg) into the deltoid muscle produced the ideal combination of rapid peak blood levels (6.5 gg...

aim and background:   pain management is very important in tonsillectomy in order to reduce the suffering and restlessness in children. the aim of this study was to investigate the effect of peritonsillar injection of lidocaine and placebo preoperatively on postoperative pain relief. methods and materials:   this randomized triple blind clinical trial conducted on sixty 3-12- year-old children ...

BACKGROUND Lidocaine demethylates deoxyribonucleic acid (DNA) in breast cancer cells. This modification of epigenetic information may be of therapeutic relevance in the perioperative period, because a decrease in methylation can reactivate tumour suppressor genes and inhibit tumour growth. The objectives of this study were to determine the effect of two amide local anaesthetics, ropivacaine and...

Objective- This study was performed to investigate the analgesic effects of lidocaine, xylazine and lidocaine/xylazine combination in epidural anesthesia in dromedary camels. Design- Experimental Study Animals- Fifteen healthy immature dromedary camels Methods- The camels were randomly designed in 3 equal groups. In group L: lidocaine 2% (0.22 mg/kg), in group X: xylazine 2% (0.17 mg/kg), an...

The authors studied the effect of changes in arterial carbon dioxide tension on plasma tidocaine concentrations dltring a constant lidocaine infusion in eight healthy volunteers. With a PaC02 of 41.4 : 0.9 mmttg (mean • SE). total plasma lido. caine concentrations were 3.97 ~0.20 tzg.ml t. There was no significant change associated with hypercarbia (PaCO 2 = 55~7 • 1.5 mmtfg, lidoeaine = 3.93 •...

Previously, we reported that local lidocaine infusion of a CA 755 mammary adenocarcinoma growing in C57BL X DBA/2 F1 mice, when combined with local heating for 1 hr in a 43.5 degrees water bath, significantly increased survival and inhibited tumor growth more than heating alone. Because of its clinical implications, systemic lidocaine was tested in the above model system and in a murine fibrosa...

BACKGROUND Opioid analgesics are commonly added to epidural local anesthetics to improve analgesia during surgery. OBJECTIVES The goal of this study was to evaluate the maternal and neonatal effects of adding different doses of tramadol to 2% lidocaine in the epidural anesthesia for cesarean section. PATIENTS AND METHODS Ninety pregnant patients who were candidates for cesarean section unde...

The effects of intravenous lidocaine were assessed in 11 patients with normal intraventricular conduction in whom reentry within the His-Purkinje system (RE-HPS) occurred consistently over a narrow range of ventricular (S,S,) coupling intervals. RE-HPS was characterized by a spontaneous beat (V9) inducible by critically timed premature stimuli (S) during constant ventricular drive (SS), and was...

PURPOSE The purpose of this study was to compare the level of patient pain during the phacoemulsification and implantation of foldable intraocular lenses while under topical, intracameral, or sub-Tenon lidocaine. PATIENTS AND METHODS This was a retrospective study. Three hundred and one eyes subjected to cataract surgery were included in this study. All eyes underwent phacoemulsification surg...

OBJECTIVE To compare the effectiveness of paracervical block, intrauterine lidocaine and oral etodolac in decreasing the pain caused by pipelle endometrial sampling. A secondary goal of this study was to determine the adverse effects and compare possible effects of these methods on pulse and blood pressure. MATERIAL AND METHODS The study was performed between April 2006 and October 2006 in th...