Paraneurons are those cells which have not been designated as neurons but are recognized as closely related to neurons on the basis of their fine structure (possession of neurosecretion-like and synaptic vesicle-like granules/vacuoles), metabolism (production of neurosecretion- and neurotransmitter-like substances) and origin (evidenced or proposed neuroectodermal). Some paraneurons are mainly ...

Lipocalin-2 (LCN2) has been implicated in promoting apoptosis and neuroinflammation neurological disorders; however, its role neural transplantation remains unknown. In this study, we cultured differentiated Lund human mesencephalic (LUHMES) cells into dopaminergic-like neurons found that LCN2 mRNA was progressively induced mouse brain after the intrastriatal of neurons. The induction protein d...

24 hours in regular medium that contained BDNF. The morphologic changes of neurons dyed by acridine orange/ethidium bromide were observed. Mitochondria membrane potential (MEP) by JC-1 dye was assessed with laser scanning confocal microscope. Lactic acid dehydrogenase (LDH) in supernatant was detected by autobiochemical analyzer. BDNF was detected by immunocytochemistry and assessed by optical ...

Chemotherapy drugs such as oxaliplatin can increase nociceptive neuron excitability to result in neuropathic pain in orofacial and other regions in patients following chemotherapy. However, mechanisms underlying chemotherapy-induced increases of nociceptive neuron excitability are not fully understood. Kv4.3 channels are voltage-gated K+ channels mediating A-type K+ (IA) currents to control neu...