نتایج جستجو برای: like receptor 9
تعداد نتایج: 1595539 فیلتر نتایج به سال:
AIM To analyze the effect of TLR-9 (-1486 T>C) and TLR-9 (C>T) gene polymorphisms both at TLR-9 levels and together with their sepsis parameters. In this regard, the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used in order to detect TLR-9 gene polymorphisms, whereas the ELISA technique was used to analyze TLR-9 serum levels in 80 sepsis patients ...
The high rate of mortality in patients with sepsis results from an inappropriately amplified systemic inflammatory response to infection. Toll-like receptors (TLRs) are important for the activation of innate immunity against microbial pathogens. We demonstrate a critical role of TLR9 in the dysregulated immune response and death associated with sepsis. Compared with wild-type (WT) mice, TLR9(-/...
PURPOSE To determine the effects of silencing Toll-like receptor (TLR) 9 signaling in Pseudomonas aeruginosa keratitis. METHODS Corneal TLR9 mRNA levels were tested by RT-PCR in C57BL/6 (B6, susceptible) and BALB/c (resistant) mice and compared. The response of B6 mice to CpG DNA, which binds TLR9, was tested after subconjunctival injection of mice with control or CpG DNA; TLR9, IL-1beta, mac...
The immune system has acquired increasing importance as a key player in cancer maintenance and growth. Thus, modulating anti-tumor immune mediators has become an attractive strategy for cancer treatment. Toll-like receptors (TLRs) have gradually emerged as potential targets of newer immunotherapies. TLR-9 is preferentially expressed on endosome membranes of B-cells and plasmacytoid dendritic ce...
Common variable immunodefi ciency (CVID) is a primary immunodeficiency involving a heterogeneous group of disorders characterized by recurrent bacterial infections and defi cient production of different classes of antibodies. The predisposing genetic factors associated with CVID remain unknown [1], although homozygous defects in ICOS or CD19 have been detected in a very small number of patients...
Published Ahead of Print 3 October 2007. 2007, 81(24):13315. DOI: 10.1128/JVI.01167-07. J. Virol. Søren R. Paludan Malmgaard, Nina Ank, Joel D. Baines, Zhijian J. Chen and Simon B. Rasmussen, Louise N. Sørensen, Lene Pathway, and Novel Recognition Systems Mitochondrial Antiviral Signaling Protein through Toll-Like Receptor 9, the Cell-Type-Specific Viral Recognition Simplex Virus Infection Is C...
OBJECTIVES There is a marked propensity for patients with acetaminophen-induced acute liver failure to develop sepsis, which may culminate in multiple organ failure and death. Toll-like receptors sense pathogens and induce inflammatory responses, but whether this is protective or detrimental in acetaminophen-induced acute liver failure remains unknown. DESIGN, SETTING, AND PATIENTS We assesse...
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