OBJECTIVE To observe effects of the drug pioglitazone on expression of hypoxia inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in diabetic rats with hindlimb ischemia, and explore the role of pioglitazone in angiogenesis after ischemia and its possible mechanism. MATERIALS AND METHODS The diabetic rat model was established by high-fat and high-sugar diet and intrape...

Background Peripheral arterial occlusive disease (PAOD) of lower extremities has been attributed primarily to atherosclerotic changes and the risk factor associated with atherosclerotic disease, including smoking, male gender, hypercholesterolemia, diabetes and age. The prevalence of CLI in general population as an adjusted rate of 3-5%. Critical limb ischemia is the most debilitating symptom o...

Arterial embolisms in the lower limbs occur frequently, and are of great interest to the vascular surgeon. The authors studied 159 cases of arterial embolisms in lower limbs from January 1991 to July 1993. Ages varied from 12 to 98, with a mean of 58. Eighty patients were male and 78 were female. In most cases, etiology of the embolus was well-established, and mainly caused (78 percent) by atri...

introduction: peripheral vascular disease (pvd) is a major cause of morbidity and is associated with coronary artery disease (cad). we aimed to perform lower limb perfusion scan (llps) in patients referred for myocardial perfusion imaging (mpi) and estimate prevalence of pvd in subgroups with normal and abnormal mpi results. we also compared quantitative indices of llps in patients with and wit...

The article presents a clinical observation illustrating the multi-stage treatment of purulent-necrotic lesions diabetic foot syndrome in presence resistant flora and critical ischemia affected limb. importance teamwork providing medical care to this category patients, as well need use adjuvant therapy, particular, bacteriophages, complex treatment, is demonstrated

Peripheral artery disease is growing in global prevalence. Its most severe form, critical limb ischemia (CLI), is associated with high rates of limb loss, morbidity, and mortality. Neovascularization is the cornerstone of limb preservation in CLI. In the field of regenerative medicine, basic research and preclinical studies have been conducted using mesenchymal stem cells (MSCs) from adult tiss...

OBJECTIVE To evaluate the predictive value of some biochemical markers in the outcome of extremity vascular trauma. METHODS This study comprised 30 patients with traumatic arterial injury and acute limb ischemia referred to Namazi hospital affiliated with Shiraz University of Medical Ssciences, over a period of 8 months, from Sep 2009 to Jul 2010. Venous blood samples were drawn from distal i...

BACKGROUND Peripheral artery disease (PAD) is a prevalent cardiovascular disorder that results in tissue ischemia which can progress to critical limb ischemia. Restoration of tissue perfusion in the setting of chronic ischemia through stimulation of arteriogenesis and angiogenesis remains a key therapeutic target for PAD. However, experimental therapeutics, including growth factor and gene ther...

The discovery of bone marrow-derived endothelial progenitors in the peripheral blood has promoted intensive studies on the potential of cell therapy for various human diseases. Accumulating evidence has suggested that implantation of bone marrow mononuclear cells effectively promotes neovascularization in ischemic tissues. It has also been reported that the implanted cells are incorporated not ...

Chronic lower limb ischemia is becoming increasingly common among patients worldwide. This a comorbid condition, which accompanied by chronic pain, trophic ulcers and gangrene, as well decrease in the quality of life. Despite nature ischemia, absence treatment high rate amputation mortality. It has been proven that with peripheral arterial disease extremities, risk cardiovascular events mortali...