Sohet et al. demonstrate that the tricellular tight junction protein LSR helps form the blood–brain barrier during embryogenesis. The blood–brain barrier protects neurons from the contents of the circulatory system and relies, in part, on the formation of tight junctions between the endothelial cells lining the blood vessels of the central nervous system. Mice lacking the tight junction protein...

In order to design composites and laminated materials, it is necessary to understand the issues that govern crack deflection and crack penetration at interfaces. Historically, models of crack deflection have been developed using either a strength-based or an energy-based fracture criterion. However, in general, crack propagation depends on both strength and toughness. Therefore, in this paper, ...

OBJECTIVE The aim of this research was to assess the relationship between mitral annular calcification (MAC) and whole blood viscosity (WBV). SUBJECTS AND METHODS A total of 184 patients with MAC and 133 patients without MAC were enrolled in the study. The WBV was calculated with a confirmed formulation using the hematocrit and total plasma protein at a low shear rate (LSR) and high shear rat...

A longstanding concept in community ecology is that closely related species compete more strongly than distant relatives. Ecologists have invoked this "limiting similarity hypothesis" to explain patterns in the structure and function of biological communities and to inform conservation, restoration, and invasive-species management. However, few studies have empirically tested the validity of th...

Abstract We report on the demonstration of low trapping effects above 1200 V GaN-on-silicon transistors using a local substrate removal (LSR) followed by thick backside ultra-wide-bandgap AlN deposition. Substrate ramp measurements show reduced hysteresis up to 3000 V. It has been found that LSR approach not only enables extension operation voltage capabilities HEMTs with on-resistance but also...

Pre-clinical animal models are important to study the fundamental biological and functional mechanisms involved in the longitudinal evolution of heart failure (HF). Particularly, large animal models, like nonhuman primates (NHPs), that possess greater physiological, biochemical, and phylogenetic similarity to humans are gaining interest. To assess the translatability of these models into human ...