abstract background ewing sarcoma is the second most frequent primary bone cancer, following osteosarcoma in children. these tumors consist of small, round, or oval cells, which are believed to derive from parasympathetic autonomic nervous system. the common clinical presentations are pain, local tenderness, fever, palpable mass, and pathologic fractures. methods and materials this study descri...

Abstract States struggle to establish multilateral cooperation on migration – yet they include more and provisions in preferential trade agreements (PTAs). This article sheds light this phenomenon by introducing the Migration Provisions Preferential Trade Agreements (MITA) dataset. Covering 797 signed between 1960 2020, dataset offers a fine-grained coding of three types provisions: those that ...

Leg Length Discrepancy (LLD) is a critical problem which not only impacts the quality of life but also causes other physical ailments such as limping and severe back pain. Most people had non-negligible difference in length their two legs, 0.1% population with differences 20 mm or more are diagnosed limb length. The Ilizarov external fixator commonly used treating LLD conventional therapeutic e...

A 7-year-old boy presented with acute-onset headache, vomiting, and confusion during summer. Two months previously, he developed right thigh pain, causing intermittent limping. Three days before admission, headache; 1 day later, experienced fatigue, nausea, vomiting. On the of presentation, symptoms included behavioral change (showered 15 times), unsteadiness, new palmoplantar rash. He lethargy...

BACKROUND: Mucopolysaccharidoses are a group of lysosomal storage diseases belonging to orphan diseases. Certain types mucopolysaccharides have typical musculoskeletal findings and radiological changes. The mucopolysaccharidosis IVB is rare type. Thus, 95% cases the IV subtype A.
 CLINICAL CASE: Сlinical changes genetic examination were performed 9-year-old patient with sensorineural deafn...

BACKGROUND Low-grade central osteosarcoma is a very rare subtype of osteosarcoma with a predilection for the metaphysis of long bones and a peak incidence in the 3(rd) decade of life. Absence of specific clinical symptoms and a good prognosis after wide resection are the characteristics of this entity. Chemotherapy is not indicated in this highly differentiated tumour. CASE REPORT A 12-year o...

Hypercalcemia is a rare metabolic disorder in children and is potentially fatal. It has a wide differential diagnosis, including cancer. Here, we report the case of a previously healthy 3-year-old who was admitted to the emergency room with fatigue, hyporeactivity, fever and limping gait that had evolved over 5 days and that was progressively worsening. On examination the patient was unconsciou...