Ca2+ channels display remarkable selectivity and permeability, traditionally attributed to multiple, discrete Ca2+ binding sites lining the pore. Each of the four pore-forming segments of Ca2+ channel alpha 1 subunits contains a glutamate residue that contributes to high-affinity Ca2+ interactions. Replacement of all four P-region glutamates with glutamine or alanine abolished micromolar Ca2+ b...

The aim of the present study was the morphometric evaluation of the epithelial lining and fibrous capsule in histological specimens of keratocystic odontogenic tumors (KOTs) before and after marsupialization. Histological sections from six KOTs that had undergone marsupialization followed by enucleation were photographed. The thickness and features of the capsule and of the epithelial lining of...

OBJECTIVES Inflammatory arthritides/synovitides such as psoriatic (PsA), reactive (ReA) and rheumatoid (RA) arthritis share numerous immunopathological features, but develop different patterns of joint involvement. To investigate whether distinctive cell apoptosis may play a role in this context, we have assessed synovial cell apoptosis in situ in PsA and ReA, and compared it with RA and 'non-i...

During an earthquake, the better performance of segmental tunnel lining, compared to the continuous in-cast concrete lining, is generally related to the joints between segments. In order to better understand the influence of the segment joints, their effect on the internal forces induced in tunnel lining simultaneously with the effects of the other influential parameters should be considered. I...

Beige mice carry a gene (bg) which codes for the presence of giant intracellular granules in a variety of cell types. Bone marrow from beige mice was transplanted into irradiated normal mice. Giant granules similar to those seen in beige mouse synovial cells were observed subsequently in the synovial lining cells of marrow recipients, indicating an influx of bone marrow derived cells into the s...

Closed-face shielded TBM driven tunnels are supported using precast concrete segmental linings. In the past these types of lining have been assessed without consideration being given to the coupling action along circumferential joints of adjacent rings or the true behaviour of joints along longitudinal joints, especially where these have a taper. The mechanical and geometrical characteristics o...

During the operation stage of cold region tunnels, isotropic surrounding rock in a freeze–thaw circle suffers long-term unidirectional cycles and gradually transforms into transversely material, which induces variation stress displacement distribution tunnels. Aimed at this phenomenon, an analytical solution mechanical response tunnels under circles induced by damage is proposed. The derived tw...

Brake lining atau kampas rem sangat penting perannya pada pesawat Cessna Grand Caravan 208B dalam mengontrol memberhentikan laju dari wheel pesawat. Dalam pengoperasian-nya brake selalu mengalami gesekan secara terus-menurus dengan disc sehingga menyebabkan material keausan, kekerasan berkurang, dan naiknya temperature drastis. Guna meningkatkan performa lining, maka ini akan diberi heat treatm...

In this technical note, a consistent finite element formulation of the Hyperstatic Reaction Method (HRM) for tunnel linings design is proposed by introducing variational consistently linearized formulation. It permits to consider nonlinear interaction between lining structure and surrounding ground. Recent advances HRM in regard consideration response segmented exposed loads use an iterative al...

abstract in this study we present successful management of an inflamed branchial cyst by stripping the inner lining thus providing a safe and definitive treatment. we believe that this is the first report of this technique in the literature.