نتایج جستجو برای: linked dextran microspheres

تعداد نتایج: 256278  

F. Inanlou H. Zolfagharian N. Mohammadpour P. Khaki,

Leptospirosis is one of the most prevalent zoonotic diseases worldwide. Currently, multivalent whole-cell leptospiral vaccines can induce protection against leptospirosis. Therefore, preparation and formulation of new generations of vaccines that can stimulate long-term immunity for leptospirosis control are essential. The aim of this study was to prepare and characterize alginate microspheres ...

H. Nojehdehian, M. Ekrami, Z. jaberi Ansari,

  Objective: In dental treatments, use of carriers for targeted antibiotic delivery would be optimal to efficiently decrease microbial count. In this study, gentamicin was loaded into polylactic co-glycolic acid (PLGA) microspheres and its release pattern was evaluated for 20 days.   Methods: In this experimental study, PLGA microspheres loaded with gentamycin were produced by the W/O/W method....

2013
Jonathan M. Behrendt David Nagel Evita Chundoo Lois M. Alexander Damien Dupin Anna V. Hine Mark Bradley Andrew J. Sutherland

The efficient transport of micron-sized beads into cells, via a non-endocytosis mediated mechanism, has only recently been described. As such there is considerable scope for optimization and exploitation of this procedure to enable imaging and sensing applications to be realized. Herein, we report the design, synthesis and characterization of fluorescent microsphere-based cellular delivery agen...

Fatemeh Atyabi Neda Islami Rassoul Dinarvand, Shadi Moghadam

     In this study, microspheres containing estradiol valerate were prepared by solvent evaporation method using poly (glycolide-co-lactide) (PLGA 50:50) and poly (lactide). The effect of different process variables such as polymer type, drugpolymer ratio, stirring rate, volume of internal phase and temperature of external phase on the morphology, particle size distribution, encapsulation effic...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2000
J M Stulak L A Juncos J A Haas J C Romero

Cross-linked hemoglobin (XL-Hb) infused into dogs increases mean arterial pressure (MAP) but decreases blood flow to the renal (RBF), mesenteric (MBF), and iliac (IBF) circulations. These actions differ markedly from dextran infusion (which increases RBF, MBF, and IBF without altering MAP) and may be due to scavenging of nitric oxide by XL-Hb. However, because the hormonal milieu regulating reg...

2015
Bei-lei Ma Pang-Hu Zhou Ting Xie Lei Shi Bo Qiu Qian Wang

BACKGROUND The previous studies indicated that CrmA could ameliorate the interleukin-1β induced osteoarthritis. In this study, we investigated the controlled-released cytokine response modifier A (CrmA) from hyaluronic acid (HA)-chitosan (CS) microspheres to improve interleukin-1β (IL-1β)-stimulated dedifferentiation of chondrocytes. METHODS A rat model of osteoarthritis (OA) in vitro was est...

2013
Dan Xu Fei Wu Yinghui Chen Liangming Wei Weien Yuan

BACKGROUND Encapsulating exogenous proteins into a nanosized particulate system for delivery into cells is a great challenge. To address this issue, we developed a novel nanoparticle delivery method that differs from the nanoparticles reported to date because its core was composed of cross-linked dextran glassy nanoparticles which had pH in endosome-responsive environment and the protein was lo...

Journal: :iranian journal of materials science and engineering 0
t. ebrahimi sadrabadi amirabad shomali, tehran, iran s.r. allahkaram amirabad shomali, tehran, iran n. towhidi amirabad shomali, tehran, iran

porous hollow glass microspheres have many uses, including encapsulation of active materials. in this paper a fast and facile method for fabricating porous hollow glass-microspheres was demonstrated by etching them using dilute hydrofluoric acid. then, a highly reactive amine was infiltrated into the etched glass microspheres. scanning electron microscopy was conducted for the hollow glass micr...

2011
Cai Jingting Liu Huining Zhang Yi

OBJECTIVE To evaluate the feasibility of using magnetic iron oxide (Fe(3)O(4))-dextran-anti-β-human chorionic gonadotropin (HCG) nanoparticles as a gene vector for cellular transfections. STUDY DESIGN Fe(3)O(4)-dextran-anti-β-HCG nanoparticles were synthesized by chemical coprecipitation. The configuration, diameter, and iron content of the nanoparticles were detected by transmission electron...

2014
Baojie Zhang Dongyang He Yu Fan Nan Liu Yijun Chen

Exenatide is an FDA-approved glucose-lowering peptide drug for the treatment of type 2 diabetes by subcutaneous injection. To address the issues on the inconvenience for patient use and the difficulty of oral administration of peptide drugs, chemical cross-linking of two pH-responsive biomaterials, alginate and hyaluronate, was carried out to prepare a new material for the encapsulation of exen...

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