نتایج جستجو برای: linking agent
تعداد نتایج: 314393 فیلتر نتایج به سال:
Existence of G-quadruplex DNA in vivo always attract widespread interest in the field of biology and biological chemistry. We reported our findings for the existence of G-quadruplex structures in promoter region of oncogenes confirmed by G-quadruplex DNA cross-linking strategy. Probes for selective G-quadruplex cross-linking was designed and synthesized that show high selectivity for G-quadrupl...
Recently, plenty of interesting studies on improvement bioavailability for poorly soluble drugs were implemented with different approaches such as using combined biopolymers a delivery system that allowed to enhancing drug solubility and bioavailability. In this work, alginate chitosan blended together in the form polymeric particles, loaded both lovastatin ginsenoside Rb1 producing four-compon...
Recent advances in bioengineering and manufacturing have catapulted Antibody–drug conjugates (ADCs) to broader clinical applications. ADCs take advantage of the exquisite specificity monoclonal antibodies (mAb) deliver a highly potent cytotoxic agent specifically targeted cell expressing selected antigen. HER2-positive breast cancer has served as testing ground for ADC development solid tumors ...
lidocaine (lc) is a local anesthetic agent. the aim of this study was to prolong the anesthetic effect of this drug in the oral cavity in the treatment of oral mucositis. films of lc were prepared with three different molecular weights (mw) of chitosan in three different concentrations (1-3%) and were then cross-linked by solvent casting evaporation method with tripolyphosphate penta sodium sal...
Chick oviduct progesterone-receptor proteins were treated in cytosol with the reversible cross-linking reagent methyl 4-mercaptobutyrimidate. The product of the reaction was a 7S complex that could be detected and recovered after sucrose-density-gradient centrifugation in 0.3M-KCl. The extent of the reaction was dependent on the concentration of methyl 4-mercaptobutyrimidate and independent of ...
Genetically encoded fluorescent cross-linking agents represent powerful tools useful both for visualising and modulating protein interactions in living cells. The far-red fluorescent protein HcRed, which is fluorescent only in a dimer form, can be used to promote the homo-dimerisation of target proteins, and thereby yield useful information about biological processes. We have in yeast cells exp...
Background: The present study aimed to analyze the situation of knowledge management among the faculty members in the four components, including creation, linking, organization and storage, and application. Methods: This is a survey research and the results are presented descriptively and analytically. The study tool was a questionnaire of knowledge management with 84 questions (creation of kno...
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