doi:10.3928/1081597X-20110412-01 C orneal ectasia remains a rare but potentially devastating complication after LASIK. In the past, treatment options have been limited; however, exciting advances have expanded our alternatives for visual rehabilitation. Any effective management strategy for ectasia after LASIK will encompass three fundamental principles: 1) halt the ectatic process; 2) reduce c...

The purpose of this article is to describe the use of simultaneous noncentered photoactivated chromophore for keratitis-corneal collagen cross-linking (PACK-CXL) combined with penetrating keratoplasty in the treatment of a severe marginal Fusarium spp. keratitis case with imminent corneal perforation. It is a retrospective case report study; it was performed by collecting clinical data, images,...

In a recent article by Laggner et al., they evaluated the applicability of second harmonic generation (SHG) imaging in the assessment of morphological and functional changes after riboflavin (RF) and ultraviolet (UV) irradiation–sensitized human corneal collagen cross-linking (CXL). To increase the efficacy of CXL through better penetration of RF into the corneal stroma, delivery of RF with ion...

PURPOSE To evaluate the outcome of collagen cross-linking (CXL) without corneal epithelial debridement in patients treated for progressive keratoconus for whom the standard epithelium-off treatment cannot be applied, as their central corneal thickness (CCT) is less than 400 μm. PATIENTS AND METHODS This was a prospective, uncontrolled, interventional study involving 32 eyes of 30 patients wit...

PURPOSE To report results of a series of highly aberrated corneas treated with a topography-guided excimer laser ablation. METHODS Retrospective, nonrandomized, consecutive series of eyes treated with topography-guided photorefractive keratectomy (TG-PRK) with the customized topographical neutralization technique (TNT). Cases included postoperative refractive surgery decentered ablations, opt...

By Yaron S. Rabinowitz, MD The use of corneal collagen cross-linking (CXL) to arrest progressive keratoconus was first introduced by Wollensak, Spoerl, and Seiler in 2003. In their initial description of the procedure, they removed the epithelium (epi-off) prior to administering riboflavin.1 These investigators have the most experience with the procedure, have experimented with different ways o...

A thirty-nine year old man was referred to our institute due to progressive decreased visual acuity five years after bilateral Laser in situ Keratomileusis (LASIK). Topography revealed signs of post - LASIK ectasia. Patients' left eye was treated with simultaneous Topography Guided Photorefractive Keratectomy (PRK) followed by Corneal Collagen Cross Linking (CXL). Twelve months after the combin...

We present here the case of a 24-year-old male who experienced progressive keratoconus and vision loss which adversely affected his ability to carry out everyday tasks. This landed him in the Hashmanis Hospital for consultation. He had a preoperative best corrected visual acuity of 6/12. He underwent multiple Oculus Pentacam examinations, which showed progressive keratoconus. Corneal collagen c...

BACKGROUND The purpose of this study was to identify differences in clinical corneal findings after standard and accelerated epithelial off cross-linking (CXL) during a long-term follow-up. METHODS Two hundred forty-one patients (184 male) were included in this monocentric, retrospective, non-randomized and unmasked study. One hundred forty-eight eyes were treated with the accelerated protoco...

Purpose To investigate riboflavin concentration on enzymatic resistance following corneal cross-linking (CXL). Methods Ninety-six porcine eyes were divided into five groups in two treatment runs. Group 1 remained untreated. Group 2 received riboflavin 0.05%, group 3 riboflavin 0.1%, group 4 riboflavin 0.2%, and group 5 riboflavin 0.3%. Treated eyes underwent CXL with ultraviolet A at 9 mW/cm2...