The R47H coding variant of the triggering receptor expressed on myeloid cells-2 (TREM2) increases the risk of Alzheimer's disease (AD) similar to apolipoprotein E4. TREM2 R47H has recently been shown to have impaired binding to damage-associated lipid or apolipoprotein ligands. However, it is not known how this R47H variant affects the biochemical characteristics of TREM2 and alters the pathoge...

The solubility of cholesterol in mixed aqueous ionic and non-ionic micellar systems in the presence and absence of salts and ionic dyes has been studied. The mixed micellar system of cetyl trimethyl ammonium bromide and Triton X-100 solubilized more cholesterol than a system consisting of sodium dodecyl sulfate and Triton X-100. The influence of salts and dyes on these systems was moderate but ...

Antioxidants are widely used in food products to preserve deterioration of their lipid components. Lately the nutraceutical properties of such compounds have driven much attention for their relationship with human health, and then natural antioxidants are preferred. Among natural antioxidants, rosemary (rosmarinus officinalis L.) has been described as one of the spices with higher antioxidant a...

The ADME of a drug involves its transport across cell membranes. This process is essential and influenced by the characteristics of the drug, especially its molecular size and shape, solubility at the site of its absorption, relative lipid solubility, etc. Over the last ten years, the number of poorly soluble drugs has steadily increased. One of the progressive ways for increasing bioavaibility...

Abstract Infectious and cancerous diseases are tedious to manage. The problem of drug resistance is often associated with anti-microbial anti-cancer agents one the most significant challenges that restrict their activity. Therefore, it necessary increase doses or combinations. However, introducing drugs in this way ineffective due poor solubility, low bioavailability, reduced stability, differe...

in this study, the ion association phenomenon in the saturated solution of kcl in the mixed solvent(methanol+water) was studied. the solubility of this compound in the mixed solvent (methanol+water by value percent of methanol = 60%), and in the presence of various molarities of nano3 wasdetermined by the solvent evaporation method at 25.0°c. the results enable us to estimate the valueof thermo...

BACKGROUND Knowledge of the fatty acid composition of lipid classes in human plasma is an important factor in the investigation of human metabolism. Therefore, a method for the analysis of neutral lipid (NL), phospholipid (PL) and free fatty acids (FFA) in human plasma has been developed and validated. METHODS Separation of lipid classes was carried out by solid phase extraction of the lipid ...

In the last decade there has been a growing interest in lipid-based formulations to deliver challenging compounds such as lipophilic drugs. Following a brief clarification of the nomenclature, this review stresses the different mechanisms of how lipid-based excipients and formulations interact with the absorption process. Case studies are presented in which enhanced bioavailability was demonstr...

Lateral segregation of cholesterol- and sphingomyelin-rich rafts and glycerophospholipid-containing non-raft microdomains has been proposed to play a role in a variety of biological processes. The most compelling evidence for membrane segregation is based on the observation that extraction with non-ionic detergents leads to solubilization of a subset of membrane components only. However, one de...