Lipodystrophy is a rare disorder that is characterized by selective loss of subcutaneous and visceral fat and is associated with hypertriglyceridemia, hepatomegaly, and disordered glucose metabolism. It has recently been shown that chronic leptin treatment ameliorates these abnormalities. Here we show that chronic leptin treatment improves insulin-stimulated hepatic and peripheral glucose metab...

F amilial partial lipodystrophy (FPL) is associated with loss of subcutaneous fat in the extremities but preservation, or increase, of fat in the face, neck, and trunk. Patients with FPL manifest marked insulin resistance and develop diabetes and hypertriglyceridemia that are often very difficult to manage with pharmacologic agents, the current standard of therapy for FPL. Roux-en-Y gastric byp...

a female one month old with features supporting a diagnosis of neonatal progeroid syndrome(wrs)  presented to our neonatology section of gb pant children hospital srinagar .she had prenatal and post natal growth failure, generalized lipotrophy, triangular face, psedohydrocephalous, sparse scalp hair and eye brows, prominent scalp veins and greatly widened anterior fontenella.

E xcessive fat storage (obesity) is associated with insulin resistance and type 2 diabetes (1). Paradoxically, inability to store fat (lipodystrophy) is also associated with insulin resistance (2). In both obesity and lipodystrophy, the adipocyte’s storage capacity is exceeded and lipids accumulate in liver, muscle, and -cells. Hypothetically, if adipose tissue had an intrinsic propensity to pr...

The lipodystrophies are a heterogeneous group of diseases characterized by generalized or partial loss of subcutaneous fat. In addition to clearly exhibiting selective loss of adipose tissue, patients are also at risk for abnormalities such as insulin resistance, hyperinsulinemia, type 2 diabetes mellitus, hyperlipidemia, glomerulonephritis, and autoimmune disorders. Advances in molecular biolo...

HIV-associated lipodystrophy includes both clinical as well as metabolic alterations. The most prominent clinical sign is a loss of subcutaneous fat (lipoatrophy) in the face (periorbital, temporal), limbs and buttocks. Peripheral fat loss can be accompanied by an accumulation of visceral fat. Truncal fat increases initially after therapy and then remains stable resulting in relative central ad...

In 1978, an 11-year-old boy began to notice proximal weakness in his limbs together with facial erythema; palpebral violaceous edema; and erythematous papules on his elbows, knees, and over the metacarpophalangeal joints. A diagnosis of polymyositis/dermatomyositis was made. He was treated with oral prednisone, which caused the symptoms to disappear promptly. In 1980, proximal weakness, dysphag...

PURPOSE Highly active antiretroviral therapy has improved the prognosis of human immuno deficiency virus type 1 (HIV-1)-infected individuals, but it has been associated with the development of metabolic and fat distribution abnormalities known as the lipodystrophy syndrome. This study tested the hypothesis that aerobic exercise training added to a low-lipid diet may have favorable effects in HI...

A patient with partial lipodystrophy, fatty liver and cirrhosis, and autoimmune thyroid disease is described. Treatment with thyroxine led to partial improvement in the hepatic abnormality.