Sebum is a well-recognised protection of the skin and minor changes on its composition quantity impact homeostasis. Over production induces microbiota dysbiosis in favor C. acnes proliferation leading to homeostasis dysbalance. Mangifera indica extract was traditionnaly used folk medicine for antibacterial antioxidant properties. In vitro studies demonstrated that main phytomarker identified, m...

Indian River male broiler chickens growing from 7 to 30 d of age were fed on diets containing crude protein levels ranging from 120 to 300 g/kg plus 0 or 1 mg triiodothyronine (T3)/kg diet. The purpose of this study was to examine the effects of these treatments on lipogenesis after a common diet was fed (180 g crude protein/kg diet from 30 to 56 d of age). Dietary treatment groups were sampled...

Sterol regulatory element-binding protein-1c (SREBP-1c) increases lipogenesis at the transcriptional level, and its expression is upregulated by liver X receptor a (LXRa). The LXRa/ SREBP-1c signaling may play a crucial role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). We previously reported that a cholesterol metabolite, 5-cholesten-3b,25-diol 3-sulfate (25HC3S), inhibits t...

Studies in rodents show that inulin and oligofructose can reduce the plasma levels of cholesterol and triacylglycerols (TG). In addition, they can oppose TG accumulation in liver and have favourable effects on hepatic steatosis. The hypotriglyceridaemic effect is due to a reduction in hepatic re-esterification of fatty acids, but mainly in the expression and activity of liver lipogenesis, resul...

PKR-like endoplasmic reticulum (ER) kinase (PERK) is an ER-associated stress sensor protein which phosphorylates eukaryotic initiation factor 2α (eIF2α) to induce translation attenuation in response to ER stress. PERK is also a regulator of lipogenesis during adipocyte differentiation through activation of the cleavage of sterol regulatory element binding protein 1 (SREBP1), resulting in the up...

Although the mechanisms linking obesity to insulin resistance (IR) and type 2 diabetes (T2D) are not entirely understood, it is likely that alterations of adipose tissue function are involved. The aim of this study was to identify new genes controlling insulin sensitivity in adipocytes from obese women with either insulin resistant (OIR) or sensitive (OIS) adipocytes. Insulin sensitivity was fi...

Bilateral transection was performed on rat sciatics. At varying intervals after the operation, samples of nerve were taken both distal and proximal to the level of transection, as well as from the tissue which bridged the gap between the stumps. These samples were incubated in Warburg flasks, with glucose and a labelled lipide precursor (acetate or phosphate). The total lipides were then extrac...

In the preceding communication (Fears & Morgan, 1976), we demonstrated that the diurnal variation in cholesterogenesis observed when acetate is used as a substrate is not apparent when 3Hz0 is used to measure the overall rate of the pathway. To investigate this difference further, and more fully to control the individual response to food, we have measured the rates of lipogenesis before and aft...

Several peptides associated with the gastrointestinal tract have hccn shown to affect the metabolism of adipose tissues for example gastric inhibitory polypeptide (GIP) and somatostatin (SS) respectively stimulate and inhibit insulin enhanced glucose uptake in isolatcd rat adipocytes [1,2]. GIP has also been reported t o enhance insulin stimulated fatty acid incorporation into rat adipose tissu...