We studied the effects of multi- and single-target liposomal drugs on human gastric cancer cell AGS both in vitro and in vivo. The cytotoxic effect of dihydrotanshinone I was significantly enhanced by treatment with octreotide-polyethylene glycol(PEG)-liposome, Arg-Gly-Asp(RGD)-PEG-liposome, and RGD/octreotide-PEG-liposome encapsulated with 0.5 mug/ml of dihydrotanshinone I to AGS cell for 24 h...

Gene delivery via transferrin receptors, which are highly expressed by cancer cells, can be used to enhance the effectiveness of gene therapy for cancer. In this study, we examined the efficacy of p53 gene therapy in human osteosarcoma (HOSM-1) cells derived from the oral cavity using a cationic liposome supplemented with transferrin. HOSM-1 cells were exposed to transferrin-liposome-p53 in vit...

The purpose of these studies was to determine the effect of Adriamycin (ADR) on the ability of liposome-encapsulated immunomodulators to activate human blood monocytes to the tumoricidal state. We undertook these experiments because we envisioned using encapsulated activators in addition to chemotherapy to destroy pulmonary micrometastases in patients with osteosarcoma (OS). Prior to the initia...

BACKGROUND Transversus abdominis plane (TAP) infiltration has been increasingly used for postsurgical analgesia in abdominal/pelvic procedures; however, duration/extent of analgesia with standard local anesthetics is limited. This pilot study assessed the preliminary efficacy and safety of two volumes of liposome bupivacaine administered via TAP infiltration in patients undergoing robotic lapar...

Over the past decade, long-circulating liposomes have successfully been employed for the purpose of targeting a variety of drugs to sites of pathology in the body. Besides target-selective accumulation, encapsulation in long-circulating liposomes can dramatically improve the pharmacokinetics of the drug. Since the pharmacokinetic behavior of liposomal agents is very different from free drugs, a...

We have investigated the tissue distribution of liposome-entrapped Adriamycin (ADM) in mice with metastatic spread to the liver and spleen after inoculation of J-6456 lymphoma cells. Sonicated phosphatidylserine:phosphatidylcholine:cholesterol liposomes were used as carriers of ADM, based on previous studies on the drug entrapment, stability, and tissue distribution of ADM-containing liposomes ...

The paper shows that there is no finite set of forbidden minors which characterizes classes of independence models that are representable by Gaussian, discrete and binary distributions, respectively. In addition, a way to prove the nonexistence of a finite characterization for any other class of independence models is suggested. MSC 2000: 60A99, 68T30, 94A15

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objective(s)cutaneous leishmaniasis is a common parasitic disease which is endemic in some parts of the world. in vitro and in vivo studies have shown azithromycin efficacy on some leishmania species. because of structural similarity between clarithromycin and azithromycin and efficacy of clarithromycin against intracellular organisms and due to the absence of previous studies in this respect, ...

one of the most important parameters describing the liposomal formulation of hydroquinone is encapsulation efficacy. for the efficacy evaluation of hydroquinone trapped in liposomal structure, there is a need to first separate liposome from the matrix surrounding it. there are various separation techniques; however, in this study, the three techniques of centrifuges with and without washing and...