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Mechanical forces are crucial to muscle development and function, but the mechanisms by which forces are sensed and transduced remain elusive. Evidence implicates the sarcolemmal lattice of integrin adhesion and the Z-disk components of the contractile machinery in such processes. These mechanosensory devices report changes in force to other cellular compartments by self-remodeling. Here we exp...

This article is an introduction to the special issue of the journal Proteins, dedicated to the sixth CASP experiment to assess the state of the art in protein structure prediction. The article describes the conduct of the experiment and the categories of prediction included, and outlines the evaluation and assessment procedures. A brief summary of progress over the decade of CASP experiments is...

We propose an alternating optimization framework for the joint design of excitation k-space trajectory and RF pulses for smalltip-angle parallel excitation. Using Bloch simulations, we show that compared with conventional designs with predetermined trajectories, joint designs can often excite target patterns with improved accuracy and reduced total integrated pulse power, particularly at high r...

In this study, we present data indicating that mammalian stem cell pluripotency-inducing factors are expressed during lens and limb regeneration in newts. The apparent expression even in intact tissues and the ensued regulation during regeneration raises the possibility that these factors might regulate tissuespecific reprogramming and regeneration. Furthermore, these factors should enable us t...

Highresolution remote sensing satellite data serve as a source for equilibrium line (EL) analysis on top of glaciers. Data fusion techniques are used in order to take advantage from both the multispectral and panchromatic information available from simultaneously acquired IRS-LISS and -PAN recordings. As a result of segmentation between snow and ice the EL is derived based on multispectral clas...

background and aims: students experience some degrees of mental disorders during their life. therefore, the present study was conducted to determine the prevalence and risk factors of mental disorders among the secondary school students in ilam, iran. methods: this is a cross sectional study, carried out among the secondary school students in ilam, iran. we assessed 841 students including 446 m...