OBJECTIVE Nur77 is an orphan nuclear receptor with pleotropic functions. Previous studies have identified Nur77 as a transcriptional regulator of glucose utilization genes in skeletal muscle and gluconeogenesis in liver. However, the net functional impact of these pathways is unknown. To examine the consequence of Nur77 signaling for glucose metabolism in vivo, we challenged Nur77 null mice wit...

Introduction Assessing lipid content in liver is of interest for number of pathologies and for observation of metabolic changes during therapy [1]. Magnetic resonance spectroscopy (MRS) is rapidly becoming the method of choice for non-invasive assessment of lipids in liver [2]. To avoid artifacts due to liver motion, MRS is often performed with a breath-hold approach [3, 4]. Given this limited ...

BACKGROUND Fatty infiltration of the liver is associated with an increased morbidity and mortality in children with severe protein-energy malnutrition (PEM), but its pathogenesis remains unclear. Although impaired synthesis of VLDL apolipoprotein B-100 (VLDL-apo B-100) is generally accepted as the pathogenetic mechanism, the rate of it synthesis has not been measured in children with PEM. OBJ...

ito cell (fat storing cell=fsc) is one of the cells which forms the liver sinusoidal wall it also forms the connective tissue of the liver. the cell was first identified in 1963 by a scientist named ito. it will get damaged due to the plasma fat increase which is resulted from a diet of corn oil 10% and fish oil 10% the damage wil be in form of fat storing cell. the fsc morphology may represent...

Abstract Liver is a by-product that can be used as raw material for nuggets because it has the nutrients needed growth especially children. Processing liver into diversification effort. Different flours will produce different final products. The purpose of this research was to determine chemical quality and amino acid profile with filler agents. materials were fresh chicken beef liver, cornstar...

We generated mice that overexpress protein targeting to glycogen (PTG) in the liver (PTG(OE)), which results in an increase in liver glycogen. When fed a high-fat diet (HFD), these animals reduced their food intake. The resulting effect was a lower body weight, decreased fat mass, and reduced leptin levels. Furthermore, PTG overexpression reversed the glucose intolerance and hyperinsulinemia ca...

PURPOSE The aim of this study was to evaluate the role of an antioxidant factor in the hepatoprotective effect of ursodeoxycholic acid (UDCA) in rat alcoholic steatohepatitis. MATERIAL AND METHODS The effects of UDCA (40 mg/kg, i.g., 30 days) were studied using rats fed on a high-fat diet (52% calories as fat) and administered with ethanol via intragastric intubation (4 g/kg daily, 30 days). ...

Hepatic steatosis is a common condition, the prevalence of which is increasing along with non-alcoholic fatty liver disease (NAFLD). Currently, the most accurate noninvasive imaging method for diagnosing and quantifying hepatic steatosis is MRI, which estimates the proton-density fat fraction (PDFF) as a measure of fractional fat content. However, MRI suffers several limitations including cost,...