Background: Zinc oxide (ZnO) nanoparticles are used for various industrial and domestic purposes and its release into the environment leads to the adverse effects among humans. This study aimed to evaluate the effect of rat exposure to ZnO nanoparticles on the histopathology of the liver and pancreas tissues, and serum oxidative stress parameters. Methods: Eighty female adult Wistar rats were ...

objectives: acetaminophen (apap) toxicity is known to be common and potentially fatal. this study aims to investigate the protective effects of hydroalcoholic extract, remaining from crocus sativus petals (csp) against apap-induced hepatotoxicity by measuring the blood parameters and studying the histopathology of liver in male rats. materials and methods: wister rats (24) were randomly assigne...

Noftji ? F' Jolly: This patient, a woman, aged 27, who was normally domiciled in Pre&n ern Ireland, first came to Bristol in February, 1956, when she was five weeks atthe j s^e ^ad had no Previous children. She was seen at Southmead Hospital given that month by Dr. P. Phillips. The date of her last menstrual period was Hth qS ?th January, 1956 from which it was calculated that she would be due ...

A woman aged 30, an inmate of a mental institution, was admitted to hospital two hours after ingesting at least 50 paracetamol tablets. She had been discovered while still swallowing some of the drug, and gastric lavage was carried out almost immediately. She had been under psychiatric care since adolescence and had received various drug therapies. Currently she was taking nortriptyline, 25 mg....

In necrosis of the liver of the dog produced by haemotoxic immune sera, the increased excretion of uric acid, purin bases and inorganic phosphorus pentoxide is the result of the hydrolysis of nuclear material occurring during the autolysis of the necrotic tissue.

1. The liver of the dog in which necrosis has been produced by injection of haematoxic immune sera is characterized in the less marked forms by a storing up of nitrogen in the persisting living cells, while in the diffuse forms the total nitrogen content is but slightly above the normal. This last is to be explained by the great diminution in persisting liver substance which limits the power of...

1. In focal and diffuse necroses of the liver due to haemotoxic sera there occurs an increased elimination of total nitrogen with a corresponding augmented output of urea. The ammonia excretion becomes slightly diminished at first, but later rises somewhat above normal. The undetermined nitrogen is markedly increased. 2. In diffuse degeneration with no necrosis on the other hand only a slightly...

Abstract In this study, D-galactose was used to establish a model of liver dysfunction caused by oxidative stress in mice, and the effect dandelion on improving exercise capacity mice with observed its mechanism expounded. This study examined role running ability, swimming endurance, blood biochemical indices, histopathological changes, tissue mRNA expression changes. The animal results showed ...

Heavy alcohol consumption over long periods of time can result in severe liver damage, including death of liver cells (i.e., hepatocytes). Two mechanisms— apoptosis and necrosis—can contribute to hepatocyte death. In apoptosis, the affected cell actively participates in the cell death process, whereas in necrosis the cell death occurs in response to adverse conditions in the cell’s environment....

The usefulness of blood enzyme determinations as markers of liver necrosis was tested in 100 alcoholics who underwent biopsy during clinical investigation. Mean values of glutamate dehydrogenase (GDH), serum aspartate and alanine transferase (SGOT and SGPT), ornithine carbamoyltransferase (OCT), and gamma-glutamyltranspeptidase (gamma-GTP) tended to rise with increasing liver cell necrosis, tho...