Two simple, rapid and inexpensive spectrophotometric methods are described for the determination of albendazole (ALB) in bulk drug and in tablets. The methods are based on charge-transfer (CT) complexation reaction involving ALB as n-donor and iodine as σ-acceptor (method A) in dichloromethane or picric acid (PA) as π-acceptor (method B) in chloroform. The absorbance of CT complexes was measure...

Recurrence quantification analysis (RQA)was used to analyse force signals during sustained sub-maximal grip contraction (SSGC) of three types of patients suffering from a metabolic muscle disorder (glycogen storage disease type III (GSD III), glycogen storage disease type V (GSD V) andmitochondrial myopathies (MITO)) compared to control subjects. Recurrence plots (RP) of patients showed clear n...

We performed morphological studies of myocardial contracture to define its nature and relationship to mechanical changes occurring during metabolic blockade. Isolated rat papillary and trabecular muscles were stretched to the apices of their length-tension curves and stimulated to contract isometrically 12 times a minute at a temperature of 28 degrees C. Incomplete and total metabolic blockade ...

The game of Twenty Questions has long been used to illustrate binary source coding. Recently, a physical device has been developed which mimics the process of playing Twenty Questions, with the device supplying the questions and the user providing the answers. However, this game differs from Twenty Questions in two ways: Answers need not be only “yes” and “no,” and the device continues to ask q...

In this work, we present an agent-based approach to multi-criteria combinatorial optimization. It allows to flexibly combine elementary heuristics that may be optimal for corresponding single-criterion problems. In the multi-criteria case a smart combination of such heuristics is supposed to efficiently approximate the whole Pareto-front of non-dominated trade-off solutions. We optimize an inst...

The effect of ethanol-water media on the synthesis of Ag/TiO2 nanocomposite was investigated with 0.05, 0.1 and 0.5 (wt.%) of Ag content. Ethanol was used as hole-scavenger enhancing the photodecomposition of Ag+ ions under illumination of near-UV light. The nanocomposites were further calcined to 300˚C and 400˚C under controlled atmosphere. The synthesized nanocomposites were tested for photoc...

Recently, it has been shown that a number of hydroxypyridinones such as 1,2-dimethyl-3-hydroxypyridin-4-one (L1) are useful for the treatment of iron overload in place of desferrioxamine in thalassaemic patients. In this study, the intestinal absorption (I.A.) of L1 and one of its analogues namely 2-methy-3-hydroxypyridin-4-one (L2), which possesses a higher partition coefficient (Kpart) than L...

Sugar cane bagasse hemicellulosic fraction was hydrolysed by treatment with 70 mg of sulphuric acid per gram of dry mass at 125 °C for 2 h. The hydrolysate was used as the substrate to grow Candida langeronii RLJ Y-019 at 42 °C; initial pH 6.0; stirring at 700 rev/min and aeration at 1.0 and 2.0 v/v/min. The utilization of D-xylose, L-arabinose, and acetic acid were delayed due to the presence ...

BACKGROUND Dantrolene is the only known effective treatment for malignant hyperthermia. However, its effects on diaphragm muscle during postnatal maturation remain unknown. METHODS The effects of dantrolene (10(-8) to 10(-4) M) were investigated in vitro on diaphragm muscle strips in adult rats and in postnatal rats aged 3, 10, and 17 days, and compared with those of ryanodine (10(-8) to 10(-...

Dihydroxylammonium 5,5'-bistetrazole-1,1'-diolate (TKX-50) is a newly synthesized energetic material with excellent comprehensive properties. Cyclotrimethylenetrinitramine (RDX) is currently one of the most widely used energetic materials in the world. TKX-50 and RDX supercell models and TKX-50/RDX cocrystal model were constructed based on their crystal cell parameters and the formation mechani...