objective: although much is known about estrogen and progesterone, their toxicity or protective effects on hepatocytes are yet to be fully understood. this study investigated the probable oxidant or antioxidant effects of estrogen and progesterone on hepg2 cell line in the presence or absence of h2o2. methods: hepg2 cells were cultured with two concentrations of estrogen and progesterone (10pm ...

estrogen replacement therapy (ert) in postmenopausal women may decrease the risk of coronary artery diseases (cad). we hypothesized that nitric oxide (no) releasing due to ert may be the essential factor by which endothelial permeability decreases. four groups of ovariectomized rabbits were under investigation for five weeks. groups 1 & 4 received high cholesterol diet and other two groups (2 &...

objectives we undertook this study to compare the results of hormone receptor assessment in cnb and surgical samples on our patients. patients and methods hormone receptor status was determined in cnb and surgical samples in breast cancer patients whose cnb and operation had been performed in this institute from 2009 to 2011 and had not undergone neoadjuvant chemotherapy. results about 350 pati...

Laparoscopic cholecystectomy is the preferred treatment for symptomatic cholelithiasis. Severe local inflammation and scar formation are commonly responsible for conversion to open surgery. Fibrosuppressive effects of estrogen on peritoneal inflammatory conditions could provide low, dense fibrosis or scar formation around the gallbladder and make laparoscopic cholecystectomy easier in women and...

Mammary stromal adipocytes constitute an active site for the synthesis of the adipokine, adiponectin (APN) that may influence the mammary epithelial microenvironment. The relationship between "local," mammary tissue-derived APN and breast cancer risk is poorly understood. Here, we identify a novel mechanism of APN-mediated signaling that influences mammary epithelial cell proliferation, differe...

Phytoestrogens are polyphenolic non-steroidal plant compounds with estrogen like activity exerted through estrogen receptors. These receptors are distributed in several tissues such as male and female reproductive systems, bones, cardiovascular and central nervous systems. These natural phenolic compounds include isoflavonoids, flavonoids, lignans and stilbenes. Isoflavonoids are the most studi...

The physiological decrease in vaginal estrogens is accountable for the emergence of vulvar and vaginal atrophy (VVA) and its related symptoms such as vaginal dryness, dyspareunia, vaginal and/or vulvar irritation or itching, and dysuria. The repercussion of these symptoms on quality of life often makes it necessary to initiate treatment. Up until now, the treatments available included vaginal m...

Introduction. Sex differences in the course and outcomes of disease were found during COVID- 19 pandemic. Aim. To summarize knowledge about mechanisms underlying sex COVID-19, with a focus on role estrogen. Materials methods. We conducted study using various databases until September 2022 for keywords “estrogen” “COVID-19”. All articles published English. Results. The review discusses involveme...

Binge eating disorder (BED) is characterized by the ingestion of a large amount of food in a short period of time and the preferential choice of high palatable food. BED is the most common eating disorder, which is associated with other medical and psychiatric complications, most notably obesity and depression [1]. The effective treatment for BED is urgently needed. We adapted a recently develo...