BACKGROUND Progressive Hemifacial Atrophy (PHA) is an acquired, typically unilateral, facial distortion with unknown etiology. The true incidence of this disorder has not been reported, but it is often regarded as a subtype of localized scleroderma. Historically, a debate existed whether PHA is a form of linear scleroderma, called morphea en coup de sabre (ECDS), or whether these conditions are...

OBJECTIVES To evaluate the esophageal involvement in patients with juvenile localized scleroderma (JLS). METHODS A cohort of patients with JLS underwent esophageal stationary manometry to evaluate esophageal motility and lower esophageal sphincter (LES) function, distal esophagus 24-hour pH-monitoring to detect gastroesophageal reflux (GER) and upper gastrointestinal (GI) endoscopy to evaluat...

308nm xenon-chloride excimer laser, a novel mode of phototherapy, is an ultraviolet b radiation system consisting of a noble gas and halide. the aim of this systematic review was to investigate the literature and summarize all the experiments, clinical trials and case reports on 308-nm excimer laser in dermatological disorders. 308-nm excimer laser has currently a verified efficacy in treating ...

Introduction Localized Scleroderma (LS) has been associated with central and peripheral nervous system involvement. Facial palsy, extra-ocular movement disorders, trigeminal neuralgia and hemi-masticatory spams are described as primary neurologic involvement. Romberg hypothesized that sympathetic regulation has pathogenic relevance in facial hemiatrophy, which was reproduced experimentally by s...

Localized scleroderma (morphea) usually develops spontaneously, but the precise mechanisms underlying disease development are obscure. However, a significant number of cases suggest that morphea is induced by external stimuli. Herein, we report a case of morphea that developed after a needle biopsy.