Objective(s) The objective of this study was to evaluate the effect of cannabinoid on cortical spreading depression (CSD) in rat brain. Cannabis has been used for centuries for both symptomatic and prophylactic treatment of different types of headaches including migraine. CSD is believed to be a putative neuronal mechanism underlying migraine aura and subsequent pain. Materials and Methods T...

OBJECTIVE To evaluate viability of luteinized granulosa cells obtained from patients triggered with either GnRH agonist or hCG and to assess the secretion of steroids and vascular endothelial growth factor (VEGF) by cultured luteinized granulosa cells in the presence or absence of hCG. DESIGN Prospective, randomized controlled trial. SETTING University-based fertility center. PATIENT(S) A...

Fear memory formation is thought to require dopamine, brain-derived neurotrophic factor (BDNF) and zinc release in the basolateral amygdala (BLA), as well as the induction of long term potentiation (LTP) in BLA principal neurons. However, no study to date has shown any relationship between these processes in the BLA. Here, we have used in vitro whole-cell patch clamp recording from BLA principa...

BACKGROUND Microdose flare-up GnRH agonist and GnRH antagonist have become more popular in the management of poor ovarian responders (POR) in recent years; however, the optimal protocol for POR patients undergoing in vitro fertilization has still been a challenge. METHODS In this observational study design, two hundred forty four poor ovarian responders were retrospectively evaluated for thei...

Abstract G protein-coupled receptors (GPCRs) are transmembrane signal transducers which regulate many key physiological process. Since their discovery, analysis has been limited by difficulties in obtaining sufficient amounts of the high-quality, functional form from heterologous expression hosts. Albeit highly attractive because its simplicity and ease isotope labeling for NMR studies, GPCRs E...

The classical problem of a time-modulated barrier, inspired by the Büttiker and Landauer model to study the tunneling times, is analyzed. We show that the traversaltime distribution of an ensemble of non-interacting particles that arrives at the oscillating barrier, obeys a distribution with a power-law tail.

IntroductionObesity has detrimental influences on women reproductive health. There is little experience in optimizing controlled ovarian hyperstimulation (COH) protocols to treat Chinese obese patients who are undergoing vitro fertilization and embryo transfer (IVF-ET) therapy.MethodsThe clinical outcome differences were retrospectively analyzed among received gonadotrophin-releasing hormone ag...