inflammatory bowel disease (ibd) is a chronic inflammatory disease affecting the gastrointestinal tract and includes ulcerative colitis and crohn’s disease. during last decades, the incidence of ibd   has increased, both in children as well as in adults (1–3). while the precise etiology of ibd is unknown, inflammatory bowel disease occure due to an abnormal immune response to luminal antigens i...

Antagonistic sexual coevolution stems from the notion that male and female interests over reproduction are in conflict. Such conflicts appear to be particularly obvious when male genital armature inflicts damage to the female reproductive tract resulting in reduced female longevity. However, studies of mating frequency, genital damage and female longevity are difficult to interpret because fema...

Thermal environments can influence many fitness-related traits including life span. Here, we assess whether longevity in Drosophila melanogaster can experimentally evolve as a correlated response to cold-stress selection, and whether genotype-by-temperature and sex-by-temperature interactions are significant components of variation in life span. Three replicated S lines were cold-stress selecte...

In order to understand the phenomenon of longevity in biological world, the relationship between the potential of longevity of an organism and its structural complexity is analyzed. I. Potential of longevity is the maximum longevity of an organism if it lives in an ideal environment. Longevity of an organism includes the time for development (developing time) and the time for structure-maintena...

In recent we introduced, developed and established a new concept, model, methodology and principle for studying human longevity in terms of demographic basis. We call the new model the " Weon model " , which is a general model modified from the Weibull model with an age-dependent shape parameter to describe human survival and mortality curves. We demonstrate the application of the Weon model to...

The recent activity in pension buyouts and bespoke longevity swaps suggests that a significant process of aggregation of longevity exposures is under way, led by major investment banks and buyout firms with the support of leading reinsurers. As regulatory capital charges and limited reinsurance capacity constrain the scope for market growth, there is now an opportunity for institutions that are...

In animals, longevity (maximal lifespan) is inversely related to mass-specific basal metabolic rates. However, contrary to expectation, in several mammalian taxa, exceptional longevity is associated with high basal metabolic rate, and also fast evolution of mtDNA-coded proteins. The association of these traits was suggested to result from adaptive selection of mutations in mtDNA-coded proteins,...

Restoration of pine forests has become a priority for managers who are beginning to embrace ideas of highly heterogeneous forest structures that potentially encourages high levels of regeneration. This study utilizes stem-mapped stands to assess how simulated regeneration timing and magnitude influence longevity of reduced fire behavior by linking growth and yield model outputs to a crown fire ...

Forkhead box class O (FOXO) transcription factors play a crucial role in longevity across species. Several polymorphisms in FOXO3 were previously reported to be associated with human longevity. However, only one Chinese replication study has been performed so far. To verify the role of FOXO3 in southern Chinese in the Red River Basin, a community-based case-control study was conducted, and seve...