Purpose: To formulate solid lipid microparticles (SLM) of loratadine (LRT) for the treatment of allergic reactions via the nasal route. Methods: Microparticles were prepared by emulsion congealing technique. The drug content of microparticles was analysed. Drug/excipient compatibility and crystallinity characteristics of microparticles were investigated by Fourier Transform Infrared Spectroscop...

2-colored best match graphs (2-BMGs) form a subclass of sink-free bi-transitive that appears in phylogenetic combinatorics. There, 2-BMGs describe evolutionarily most closely related genes between pair species. They are explained by unique least resolved tree (LRT). Introducing the concept support vertices we derive an $O(|V|+|E|\log^2|V|)$-time algorithm to recognize and construct its LRT. The...

As part of the Central Phoenix/East Valley Light Rail Transit Project, the Cities of Phoenix, Tempe and Mesa, Arizona are proposing a new light rail line, part of which will follow Central Avenue, a major north-south corridor in the City of Phoenix. The service is expected to initially operate with approximately 6-minute headways in both directions. The LRT tracks will be in the center median a...

B. A Keogh, M.D.; and R. C. Crystal, M.D. I diopathic pulmonary fibrosis (IPF) and a,-antitrypsin deficiency (a,AT def) are both associated with a chronic influx of neutrophils to the alveolar structures, yet the pathophysiologic consequences of this neutrophil accumulation are strikingly diverse in the 2 disorders. To assess the role of neutrophil proteases and oxidative products in determinin...

This Monte Carlo study assessed Type I error in differential item functioning analyses using Lord’s chi-square (LC), Likelihood Ratio Test (LRT), and Mantel-Haenszel (MH) procedure. Two research interests were investigated: response theory (IRT) model specification LC the LRT continuity correction MH enhances literature by investigating correct incorrect model-data fit comparing those results t...

Statistical association studies are an important tool in detecting novel disease genes. However, for sequencing data, association studies confront the challenge of low power because of relatively small data sample size and rare variants. Incorporating biological information that reflects disease mechanism is likely to strengthen the association evidence of disease genes, and thus increase the p...

Recent research has revealed loci that display variance heterogeneity through various means such as biological disruption, linkage disequilibrium (LD), gene-by-gene (G × G), or gene-by-environment interaction. We propose a versatile likelihood ratio test that allows joint testing for mean and variance heterogeneity (LRT(MV)) or either effect alone (LRT(M) or LRT(V)) in the presence of covariate...

Meta-analysis of genetic data must account for differences among studies including study designs, markers genotyped, and covariates. The effects of genetic variants may differ from population to population, i.e., heterogeneity. Thus, meta-analysis of combining data of multiple studies is difficult. Novel statistical methods for meta-analysis are needed. In this article, functional linear models...

This paper presents a new experimental approach to simulate projected autonomous driving styles based on the accelerations at three road profiles. This study was focused on the determination of ranges of accelerations in triaxial direction to simulate the autonomous driving experience. A special device, known as the Automatic Acceleration and Data controller (AUTOAccD), has been developed to gu...

A new method is developed for estimating rates of somatic mutation in vivo. The stop-enhanced green fluorescent protein (EGFP) transgenic mouse carries multiple copies of an EGFP gene with a premature stop codon. The gene can revert to a functional form via point mutations. Mice treated with a potent mutagen, N-ethyl-N-nitrosourea (ENU), and mice treated with a vehicle alone are assayed for mut...