We compared the powers of the likelihood ratio test (LRT) and the Pearson correlation test (CT) from empirical Bayes estimates (EBEs) for various designs and shrinkages in the context of nonlinear mixed-effect modeling. Clinical trial simulation was performed with a simple pharmacokinetic model with various weight (WT) effects on volume (V). Data sets were analyzed with NONMEM 7.2 using first-o...

Purpose: To prepare solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) of loratadine (LRT) for the treatment of allergic skin reactions. Methods: SLN and NLC were prepared by high pressure homogenization method. Their entrapment efficiency (EE) and loading capacity (LC) were determined. The physical stability of nanoparticles was investigated during 6 months of storage at r...

It has been shown that patients with hepatocellular carcinoma (HCC) meeting the United Network for Organ Sharing T2 (Milan) criteria have an advantage in comparison with patients without HCC under the current organ allocation system for liver transplantation (LT). We hypothesized that within the T2 HCC group, there is a subgroup with a low risk of wait-list dropout that should not receive the s...

Converging evidence suggests that stuttering is associated with deficits in the planning and execution of speech. Evidence also suggests that the onset, development, and loci of stuttering are related to demands language places on speech motor planning and execution. We combined linguistic and vocal motor assessments to address two questions: 1) Can we identify a subgroup of adult stutterers wh...

Using male/female and Caucasian/African American comparison groups, this study examined the practical ramifications of using two IRT-based analytic methods, DFIT and the Likelihood Ratio Test (LRT), in assessing the measurement invariance of a 21-item leadership development scale under ten sample size conditions (e.g., 200, 500, & 1000). In nine of ten conditions, the LRT identified multiple it...

It has been shown that in optical communication systems with detectors that have a multiplicative noise component, the bit error rate (BER) can be improved by orders of magnitude through the use of a thresholding scheme based on a likelihood ratio test (LRT) instead of a matched filter [1]. An LRT detection scheme of this type has been derived previously for optically encoded Manchester data [1...

The selective pressure at the protein level is usually measured by the nonsynonymous/synonymous rate ratio (omega = dN/dS), with omega < 1, omega = 1, and omega > 1 indicating purifying (or negative) selection, neutral evolution, and diversifying (or positive) selection, respectively. The omega ratio is commonly calculated as an average over sites. As every functional protein has some amino aci...

We previously demonstrated that blockade of immune suppressive CTLA-4 resulted in tumor growth delay when combined with chemotherapy in murine mesothelioma. Tumor-infiltrating T cells (TIT) after local radiotherapy (LRT) play critical roles in abscopal effect against cancer. We attempt to improve the local and abscopal effect by modulating T cell immunity with systemic blockade of CTLA-4 signal...

BACKGROUND AND PURPOSE An extradurally located cavernous sinus dural arteriovenous fistula (CSDAVF) exhibits different clinical behavior from other dural arteriovenous fistulas (DAVFs) located between 2 dural leaves. The aim of this study is to define angiographic types of CSDAVF associated with presenting symptom (Sx) and venous drainage patterns. METHODS CSDAVFs during a mean of 23-month fo...

PURPOSE The aim of this work was to analyze the results and complications of three treatment schemes of patients with initially localized prostate cancer after two years of observation time. MATERIAL AND METHODS Sixty-three patients were enrolled into the study and divided into groups according to radiation schemes (I group - EBRT 50 Gy/BRT 15 Gy, II - EBRT 46 Gy/BRT 2 × 10 Gy, III group - BR...