We report the clinical trial studies for the ThinPrep Imaging System (TIS; Cytyc, Boxborough, MA). Between December 2000 and July 2001, 10,742 ThinPrep specimens were collected at 4 US clinical sites representative of the normal clinical population of the laboratories, including screening patients and referred patients. After nonstudy screening diagnoses were completed, the vials were relabeled...

OBJECTIVE Both PCR and Hybrid Capture II (HCII) have been used for identifying cervical dysplasia; however, comparisons on the performance between these two tests show inconsistent results. We evaluated the performance of HCII and PCR MY09/11 in both screening and diagnostic populations in sub-sample of 1,675 non-pregnant women from a cohort in three clinical centers in the United States and Ca...

BACKGROUND The accuracy of cervical cytology has been questioned due to high false negative rate. In order to improve the sensitivity of cytology it is prudent to analyze the factors which hamper with the diagnosis of high grade lesions. AIMS To study the cyto-histologic agreement in High grade squamous intraepithelial lesions (HSIL) of uterine cervix and to analyze the smear characteristics ...

Background & Objective: Cervical cancer is the most common cancer in women worldwide with high mortality, necessitating quicker diagnostic methods. We wish to enhance th...

Tucson, AZ, June 16, 2015 Ventana Medical Systems, Inc. (Ventana), a member of the Roche Group, today announced the publication of further results from the Primary ASCUS LSIL Marker Study (PALMS) in this month’s issue of Cancer Cytopathology1. The PALMS study, which enrolled more than 27,000 women from five European countries, was designed to evaluate the diagnostic performance of the CINtec® P...

AMAÇ: Bu çalışmada, smear sonucu düşük dereceli servikal intraepitelyal lezyon (LSIL), yüksek intraepiteliyal (HSIL), önemi belirsiz tipik olmayan yassı hücreler (ASCUS) tespit edilen, muayenede erzoyon saptanan hastalar ve yapılan human papilloma virüs (HPV) testi pozitif olan takiben kolposkopik biyopsi uygulanan hastalarımızda HPV, sonuçları karşılaştırılması amaçlanmıştır.GEREÇ VE YÖNTEM: T...

Introduction: Cervical cancer is common and ranked in fourth place both incidence mortality worldwide. It 3rd most female Malaysia with a lifetime risk of 1 116. Infection high-risk oncogenic human papillomavirus (HPV) recognized as one the substantial factors for development cervical cancers. Methods: was cross-sectional study conducted to determine prevalence HPV infection its subtypes among ...

BACKGROUND & OBJECTIVES High-risk human papilloma virus (HR-HPV) infection and its integration in host genome is a key event in malignant transformation of cervical cells. HPV16 being a dominant HR-HPV type, we undertook this study to analyze if viral load and physical state of the virus correlated with each other in the absence of other confounding variables and examined their potential as pre...

Background: Cervical cancer in India accounts for 1/4 th cancer burden of world. Morbidity and mortality due to cervical cancer declined dramatically in developed countries after introduction of cytology based screening programs and quality treatment. ObjectiveTo find out proportion of and pattern of cellular atypia and dysplasia, to evaluate ASCUS/ LSIL cases with colposcopy, HPV testing and h...

Persistent infections by high-risk types of human papillomavirus (HPV) have been established as the etiological agent of cervical cancer. The integration of the HPV genome into the host genome is a crucial step in cervical carcinogenesis, although, correct activation of DNA damage repair pathways will avoid the development of cancer. Recent data indicate that several polymorphisms of key regula...