The increasing interest in combined positron emission tomography (PET) and computed tomography (CT) to guide lung cancer radiation therapy planning has been well documented. Motion management strategies during treatment simulation PET/CT imaging and treatment delivery have been proposed to improve the precision and accuracy of radiotherapy. In light of these research advances, why has translati...

The purpose of this study was to test the feasibility of using respiratory correlated mega voltage cone-beam computed tomography (MVCBCT), taken during patient localization, to quantify the size and motion of lung tumors. An imaging phantom was constructed of a basswood frame embedded with six different-sized spherical pieces of paraffin wax. The Quasar respiratory motion phantom was programmed...

Studying complex thorax breating motion is an important research topic for accurate fusion of functional and anatomical data, radiotherapy planning or reduction of breathing motion artifacts. We investigate segmented CT lung, airway and diaphragm surfaces at several different breathing states between Functional Residual and Total Lung Capacity. In general, it is hard to robustly derive correspo...

Breathing motion is one of the major limiting factors for reducing dose and irradiation of normal tissue for conventional conformal radiotherapy. This paper describes a relationship between tracking lung motion using spirometry data and image registration of consecutive CT image volumes collected from a multislice CT scanner over multiple breathing periods. Temporal CT sequences from 5 individu...

Introduction: MRI of the lung is still a challenging task due to its inherently low proton density, continuous movement caused by respiration and heartbeat, as well as a very short T2* relaxation time of roughly 1-2 ms at 1.5 T [1]. The latter of which can be overcome by using Spin-Echo type sequences which correct for additional spin dephasing owing to inhomogeneities at the numerous air-tissu...

The use of PET in the staging of patients with NSCLC is cost-effective, mainly due to a reduction in the number of futile operations. The addition of SUVmax to pathologic tumor size identifies a subgroup of patients at highest risk for death as a result of recurrent disease after resection. Tumor staging is more accurate with PET-CT than with CT alone or with PET alone. The greatest source of e...

During radiotherapy treatment for thoracic and abdomen cancers, for example, lung cancers, respiratory motion moves the target tumor and thus badly affects the accuracy of radiation dose delivery into the target. A real-time image-guided technique can be used to monitor such lung tumor motion for accurate dose delivery, but the system latency up to several hundred milliseconds for repositioning...

Among other options, radiotherapy plays an increasing role for the treatment of lung cancer. This has raised the need for strategies to compensate for respiratory motion of the target. Sophisticated techniques such as tracking of the tumour position have become feasible. However, calculations for adequate dose delivery to moving targets with maximum preservation of healthy tissue require unders...

inflammatory responses and innate immunologic reactions play an important role in the respiratory system. ex vivo lung perfusion (evlp) is considered a novel method in the evaluation and reconditioning of donor lungs prior to transplantation. however, evlp’s effect on inflammatory and metabolic markers of human lung tissue is unknown. this study investigated how the performance of evlp on brain...

An Essay on the Forces which circulate the "Blood; being an Examination of the Difference of the Motions of Fluids in Living and Dead Vessels. By Charles Bell, F. R. S. E. Surgeon to the Middlesex Hospital, &c. One Vol. Duodecimo, 83 Pages. London, 1819. When we say that the blood returns or is returned (for we dare not be positive on this point) from the general venous system to the right auri...