Increasing evidence suggests tumors are maintained by cancer stem cells; however, their nature remains controversial. In a HoxA9-Meis1 (H9M) model of acute myeloid leukemia (AML), we found that tumor-initiating activity existed in three, immunophenotypically distinct compartments, corresponding to disparate lineages on the normal hematopoietic hierarchy--stem/progenitor cells (Lin(-)kit(+)) and...

Bexarotene is an oral retinoid shown to be active against the cutaneous manifestations of cutaneous T-cell lym-phoma (CTCL). Literature on the efficacy, dosing and side-effects of bexarotene is sparse. We present here data on 37 Finnish patients with CTCL treated with bexarotene during the last 10 years. Bexarotene was equally effective as monotherapy or when combined with other treatment modal...

Niacin may cause evaporative thermolysis through cutaneous hyperemia, vasodilation, increased sweating rate and decreased skin temperature. It is antilipolytic can improve metabolic responses. Heat stress ameliorative effects of rumen protected niacin (RPN) supplementation in lactating Surti buffaloes during summer has been investigated present study. Fourteen were divided into two groups (Cont...

Nasal polyposis represents as a chronic hyperplastic sinusitis associated with chronic inflammation. In present retrospective study, we aimed to compare the Mean Platelet Volume (MPV), Red Cell Distribution Width (RDW) and Neutrophil to Lymphocyte Ratio (NLR) values of patients with nasal polyposis to those in healthy subjects. We included 35 nasal polyp patients and 45 healthy subjects into th...

Successful treatment of melanoma and lymphoma may result from the induction of specific antitumor immunity. Dendritic cells (DCs) are pow erful antigen-presenting cells and show a remarkable capacity to stimulate antigen-specific T-cell responses. Administration of FLT3 ligand (FL) results in a reversible accumulation of functionally active DCs in both lymphoid and nonlymphoid tissues. Therefor...

We have investigated the capacity of polymorphonuclear phagocytes (PMN) to lyse malignant B-cell lines using antibodies and antibody derivates to a range of different B-cell antigens. PMN were found to mediate lysis of all tested Bcell lines in the presence of HLA class II antibodies L227, L243, F3.3, and CR3/43. Target cell lysis was significantly enhanced when PMN isolated during granulocyte ...

Continuous lymphoblastoid cell cultures were established from marmoset (Saguinus sp.), squirrel (SaimirÃ-sciureus), owl (Aotus trivirgatus), and cebus (Cebus apella) monkeys after their peripheral lymphocytes were cultured with lethally, X-irradiated cells carrying Epstein-Barr virus (EBV). Simian lymphocytes were also transformed after exposure to infectious, cell-free EBV derived from some si...

With a newly developed turbidometric method, concana valin A was shown to agglutinate normal lymphocytes, lym phoma cells, and leukemic cells from chronic lymphocytic leukemia and from acute myelocytic and lymphocytic leuke mia. However, there was a marked difference in the kinetics of this agglutination process. Leukemic blast cells and cells from a patient with convoluted lymphoma agglutinate...

Identifying fake news is crucial in the fight against misinformation. To achieve this goal, our project employs SVM and NB algorithms. We also utilize sentiment information from labeled unlabeled data to improve classifiers’ understanding of each trend. With proliferation internet, there a growing volume dubious intentional lym leading content. The quality can be so high that it challenging dif...

Introduction: Preoperative classification of brain tumors such as intra-axial from extra-axial tumors, glioblastomas (GBM) from brain metastatses (MET) and astrocytomas (AS) from oligodendrogliomas (OLG) is important as these histological subtypes are treated differently. Previous studies have reported the potential of H MRS in classification of different histological subtypes with variable deg...