Background: Papillary thyroid carcinoma (PTC) located in the isthmus generally has been known to have more extrathyroidal extension (ETE), lymph node involvement, and multifocality. The purpose of this study was determine clinical significance an isthmic location PTC.

background and objectives: the most prevalent malignancy among women is known to be breast cancer (bc). several factors contribute to determining tumor prognosis and treatment strategies. in this study, the frequency and relevance of these factors are discussed. materials and methods: this cross-sectional study was carried out on 214 patients with bc, who referred to the cancer institute of im...

background: e-cadherin is a calcium-dependent molecule that contributes to intercellular adhesion. its proper functioning is important in the maintenance of epithelial structure and integrity. e-cadherin serves as a very important tumor suppressor. in this study, we aimâ to determineâ the frequencyâ of e-cadherin expression aberrancy and its relationship to theâ biologicalâ behavior of gastric ...

BACKGROUND The aims of this retrospective analysis were to evaluate the effect of combined superficial and deep groin dissection on disease-free and melanoma-specific survival, and to identify the most important factors for predicting the involvement of deep nodes according to clinically or microscopically detected nodal metastases. METHODS Between January 1996 and December 2005, 133 consecut...

background: in an attempt to reduce the risk of developing lymphedema following breast cancer surgery, some researchers suggested that by identifying and preserving the lymphatic plexus which drains ipsilateral arm we can minimize the risk of lymphedema. the procedure is known as axillary reverse mapping (arm). in the current study, we investigated the oncological safety of this technique. meth...

background: considering molecular target therapy concept in the treatment of oral squamous cell carcinoma (oscc), many attempts have been performed to introduce an effective molecular marker during recent years. several investigations have emphasized on the role of cd44 in various cancers and few studies have mentioned cd24 and cd74. the purpose of this study was to investigate the relationship...

background : sentinel lymph node biopsy is a technique used to identify the axillary node most likely to contain tumor cells that have metastasized from a primary carcinoma of the breast. this technique provides accurate staging with fewer complications than axillary dissection and may result in decreased costs. we designed the present study to determine the accuracy and success rate of a combi...

Since the routine clinical use of the sentinel lymph node (SLN) procedure, questions have been raised concerning an increase in the overall percentage of node-positive patients. The goal of our study was to compare the sensitivity of the SLN procedure and the axillary lymph node dissection (ALND) for the identification of positive lymph nodes in breast cancer. The incidence of axillary node met...

  Background and Objective: Oral cancer accounts for less than 3% of all cancers. Despite recent improvement in diagnostic and treatment methods, the overall survival of the disease is unfavorable. Several studies have been performed to assess factors influencing lymph node metastasis and prognosis. The aim of this study was to evaluate some clinical and pathological factors influencing lymph ...