Lymphatic vessels maintain tissue fluid homeostasis by returning to blood circulation interstitial that has extravasated from the capillaries. They provide a trafficking route for cells of immune system, thus critically contributing surveillance. Developmental or functional defects in lymphatic vessels, their obstruction damage, lead accumulation tissues, resulting lymphedema. Here we discuss d...

It has generally been accepted that the blood vascular system is primary and the lymphatic vascular system secondary. Diseases of the blood vascular system are the leading cause for mortality and morbidity in developed nations. In contrast, lymphedema is seldom life-threatening and can generally be well-managed by combined physiotherapy. During ontogeny, the blood vessels and the heart develop ...

The growth of lymphatic vessels (lymphangiogenesis) is actively involved in a number of pathological processes including tissue inflammation and tumor dissemination but is insufficient in patients suffering from lymphedema, a debilitating condition characterized by chronic tissue edema and impaired immunity. The recent explosion of knowledge on the molecular mechanisms governing lymphangiogenes...

By ROWLAND J. CALVERT AND ERIC SMITH P ERIPHERAL MANIFESTATIONS in lymphatic leukemia are well recognized. They may domimiat.e the climiical picture amid closely simulate other diseases. The unique amid confusimmg acral sighs imi this illustrative case merit detailed description. The only similar case recorded is that of Schit.tenhelm.’ Rhinophyma ‘as, how-ever, an additional feature in our pat...

lymphangioma circumscriptum is a benign lymphatic malformation which is localized to the skin and subcutaneous tissues. it consists of dilated lymph channels lined by normal endothelium.primary vulvar involvement is very rare and only 28 cases have been reported till 2002. here we report a case in an 18 years old girl who was referred to our gynecologic clinic with symptoms of pain,swelling and...

Lymphangiogenesis is a dynamic process that involves the sprouting of lymphatic endothelial cells (LECs) from veins to form lymphatic vessels. Vegfr3 signalling, through its ligand Vegfc and the extracellular protein Ccbe1, is essential for the sprouting of LECs to form the trunk lymphatic network. In this study we determined whether Vegfr3, Vegfc and Ccbe1 are also required for development of ...

Lymphoedema (LOE) is an under-diagnosed condition which can cause severe incapacitating swelling of the extremities. Misdiagnosis and/or delayed diagnosis are common and the goal of further evaluation is to confirm the cause and determine the type and site of lymphatic obstruction. Lymphoscintigraphy (LSG) is a minimally invasive way of evaluation of the lymphatic system and can be used in the ...

This study was undertaken to explore the effects of lymphatic blockage on the metabolism of hyaluronan in the skin. In initial experiments, [3H] hyaluronan was injected subcutaneously into the tail skin of rats that either had no surgical intervention (control) or into those that had their lymphatic drainage blocked two hours earlier (acute lymphedema) or after the lymphatics had been blocked f...