نتایج جستجو برای: lymphatic system
تعداد نتایج: 2245035 فیلتر نتایج به سال:
Our interest in the effects of impaired cardiac lymph drainage on coronary atherosclerosis led us to study the cardiac lymphatic anatomy in the monkey, generally considered the ideal experimental animal for examining coronary artery disorders. Short-term and long-term studies to visualize the cardiac lymphatic system and its mediastinal drainage pathways in 14 living monkeys confirmed that the ...
The lymphatic vascular system is necessary for the return of extravasated interstitial fluid and macromolecules to the blood circulation, for immune defense, and for the uptake of dietary fats. Impaired functioning of lymphatic vessels results in lymphedema, whereas tumor-associated lymphangiogenesis may contribute to the spread of cancer cells from solid tumors. Recent studies have identified ...
The major function of the lymphatic system is to drain interstitial fluid from tissue. Functional drainage causes increased fluid flow that triggers lymphatic expansion, which is conceptually similar to hypoxia-triggered angiogenesis. Here, we have identified a mechanotransduction pathway that translates laminar flow-induced shear stress to activation of lymphatic sprouting. While low-rate lami...
The lymphatic vascular system mediates fluid homeostasis, immune defense, and tumor metastasis. Only a handful of genes are known to affect the development of the lymphatic vasculature, and even fewer represent therapeutic targets for lymphatic diseases. Adrenomedullin (AM) is a multifunctional peptide vasodilator that transduces its effects through the calcitonin receptor-like receptor (calcrl...
Obesity is a major risk factor for inflammatory dermatologic diseases, including atopic dermatitis and psoriasis. In addition, recent studies have shown that obesity impairs lymphatic function. As the lymphatic system is a critical regulator of inflammatory reactions, we tested the hypothesis that obesity-induced lymphatic dysfunction is a key regulator of cutaneous hypersensitivity reactions i...
INTRODUCTION Lymphatic vessels are important for the regulation of tissue fluid homeostasis, immune surveillance and dietary fat absorption (Tammela and Alitalo, 2010). Aberrant lymphatic growth is associated with pathological conditions, including cancer metastasis and chronic inflammation, while a malfunctioning lymphatic system results in lymphoedema (Alitalo, 2011). Fuelled by the identific...
The circulatory system of mammals consists of 2 components, blood vessels and lymphatic vessels, which are counterparts that act in parallel but develop in series. Unlike blood vessels that are a system built up to form a closed circuit carrying circulating blood, lymphatic vessels differ in that it is an open system with unique architecture starting at its periphery as a blunt end specialized ...
22 The main physiological function of the lymphatic vasculature is to maintain tissue fluid 23 homeostasis. Lymphangiogenesis or de novo lymphatic formation is closely associated with 24 tissue inflammation in adults (i.e. wound healing, allograft rejection, tumor metastasis). 25 Until recently, research on lymphangiogenesis focused mainly on growth factor/growth 26 factor-receptor pathways gov...
lymphatic filariasis (lf), a nematode disease transmitted by arthropod vectors, is repeatedly reported in immigrant population. this disease is not endemic in iran; however, different species of mosquitoes, capable of transmission of parasite mi-crofilaria, are distributed in the country. hereby, incidental detection of an im-ported case of lf due to wuchereria bancrofti in an indian worker in ...
The lymphatic system is indispensable for the collection and cycling of tissue-extravasated fluids, macromolecules and immune cells into the bloodstream. Different mechanisms, including sprouting, ballooning and budding of lymphatic endothelial cells from the cardinal vein, have been proposed for lymphatic vessel formation during mammalial embryogenesis. Hägerling et al (2013) now provide a cel...
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