Background Cigarette smoking is a well-described risk factor for a number of cancers and has been implicated as the most significant cause of urothelial cancer, conferring up to a 7-fold increased risk. Urothelial cancers are also part of the spectrum of cancers associated with Lynch syndrome. Several studies have looked at the impact of gene-environment interaction on cancer risk in Lynch synd...

Background Inherited cancer syndromes associated with acoustic neuroma (i.e. neurofibromatosis 2-NF2), pheochromocytoma (i.e. Von Hippel Lindau, NFl, multiple endocrine neoplasia syndromes, and hereditary paraganglioma syndrome), and colon cancer are well known. Lynch syndrome is the most common hereditary colon cancer syndrome and is caused by DNA mismatch repair dysfunction secondary to inher...

Hereditary ovarian cancer accounts for at least 5% of the estimated 22,000 new cases of this disease during 2009. During this same time, over 15,000 will die from malignancy ascribed to ovarian origin. The bulk of these hereditary cases fits the hereditary breast-ovarian cancer syndrome, while virtually all of the remainder will be consonant with the Lynch syndrome, disorders which are autosoma...

The evidence for genetic testing for the adenomatous polyposis coli (APC) mutation in individuals with a clinical differential diagnosis of attenuated familial adenomatous polyposis (aFAP), MUTYHassociated polyposis and Lynch syndrome, or individuals who are at-risk relatives of patients with FAP, includes a TEC Assessment. Outcomes of interest are overall survival, disease-specific survival, t...

SUMMARY RINT1 is a novel moderately penetrant cancer susceptibility gene seen in breast cancer as well as possibly in Lynch syndrome-related cancers.

Lynch syndrome (LS) is a common hereditary caused by mutations in deoxyribonucleic acid mismatch repair genes, with high probability of gastrointestinal, gynaecological and other cancers. The most LS-associated gastric cancer adenocarcinoma the intestinal type. Neuroendocrine neoplasia has not been well understood cancer. Herein, we report case 68-year-old female, history ascending colon seven ...

Lynch syndrome is a hereditary cancer predisposition syndrome caused by germline loss of a DNA mismatch repair gene. In a significant proportion of cases, loss of function of the MSH2 mismatch repair gene is caused by large heterogeneous deletions involving MSH2 and/or the adjacent EPCAM gene. These deletions usually result from homologous malrecombination events between Alu elements, a family ...

•First report of Lynch syndrome in a Vietnamese kindred•A novel MSH2 mutation has been identified.•Culturally sensitive screening programs need to be developed in this growing population.

The conference covered several contemporary topics like apoptosis, angiogenesis and several interesting and insightful talks were presented by the delegates. The keynote addresses ' Cancer predisposition', on the opening day by Dr. HT Lynch, the father of lynch syndrome, a hereditary non polyposis colorectal cancer (HNPCC) is a highlight of the symposium. There were several talks on dietary inf...