introduction: bone pain palliation therapy is a mandate in handling end-stage cancer patients. the development of new ligands with higher stability, better pharmacokinetics and lower unwanted tissue uptakes (liver and gi) is still ongoing. methods: in this work lu-177 labeled (3-amino-1-hydroxypropane-1,1-di-yl)-bis-(phosphonate) (177lu-pamidronate; 177lu-pam ), and (3-amino-1-hydroxybutane-1,1...

introduction during the process photodynamic therapy (pdt), bleaching of photosensitizer induced by irradiation and generation of reactive oxygen species (ros) can provide some information concerning the efficiency of treatment. since gold nanoparticles (gnps) have been highlighted as efficient drug delivery systems, in this study, by utilizing gnps conjugated with 5 aminolevulinic acid (5-ala-...

there exists compelling evidence that toll-like receptor 3 (tlr3) agonists can directly affect human cancer cells. the aim of this study was to investigate anti-cancer effects of tlr3 agonist in human breast cell line. we assessed potential effects of poly (a:u) on human breast cell line (mda-mb-231)  on a dose-response and time-course  basis. human breast cell line  mda-mb-231  was treated wit...

background: acute lymphoblastic leukemia is a lymphoid malignancy, resulting from autonomous proliferation of monoclonal abnormal stem cell. the aim of this study was to evaluate the response rate and prognostic factor of adult patients suffering from acute lymphoblastic leukemia, who were treated with chemotherapy in south east of iran and demographic methods were used for this study.   method...

tetrahydrobenzo[b]pyran derivatives 1 were utilized for the synthesis of several new pyrano[2,3-d]pyrimidine derivatives 2. compound 2 was obtained in the presence of ac2o/h2so4 (as a catalyst) and was confirmed by spectroscopic data such as ir, 1h nmr and 13c nmr. ab initio calculation was carried out to study geometric optimization, thermodynamic parameters, aromaticity and dynamic process of...

objective(s): human and animal studies have shown a close relationship between obesity and asthma severity. here, we examined the effects of diet-induced obesity (dio) on the expression levels of il-1β, irak-1 and traf-6 mrna in male wistar rats tracheal after sensitization with ovalbumin (ova). materials and methods:twenty male wistar rats divided to four groups, included, control group with n...

background and objectives: bitter melon is one of the anti-cancer medicinal plants that it’s wide level in vitro propagation and anti-cancer material production was necessary. different factors such as genotype, selected explants’ type and it`s preparation conditions influenced regeneration content. plant growth regulator`s effect on callogenesis and indirect regeneration from parangipetai indi...

retinoblastoma is the most common intraocular tumor in children resulting from genetic alterations and transformation of mature retinal cells. the objective of this study was to investigate the effects of sd-208, tgf-β-ri kinase inhibitor, on the expression of some mirnas including a mir-17/92 cluster in retinoblastoma cells. prior to initiate this work, the cell proliferation was studied by me...

tio2 nanoparticles were synthesized by modified sol—gel method using pure room temperature ionic liquid(rtil) 2-hydroxyethylammonium formate as a reaction medium. the structure and morphology of tio2nanoparticles were characterized with x-ray powder diffraction (xrd), bet surface analysis and scanningelectron microscopy (sem). tio2 nanoparticles were synthesized in open and closed vessels. the ...

background: colorectal cancer is one of the most important causes of morbidity and mortality in the world. it has been suggested that tissue inhibitor of metalloproteinase-1 (timp-1) plays a particular role in cancer promotion. the objective of the present study was to compare the effect of repeated measurement of carcinoembryonic antigen (cea) and timp-1 plasma levels in a follow-up response t...