Hypertension, or high blood pressure, is a major public health concern around the world because of its large contribution to global burden and function as risk factor for variety disease processes. Bosentan SR Floating Bilayer Tablets were made with HPMC K4M, E-15, E-15 alone (80%) in combination varying percentages polymer (20&60 percent, 40&40 60&20 percent ). The hydrophilic used...

There has been much recent interest in the role of a calcium-dependent, phospholipid-dependcnt protein kinase (PKC) in regulation of macro phage function and growth. In order to better define the role of PKC in these processes we have developed mutants of the RAW264 macrophagelike cell line that are resistant to the growth-inhibiting effects of 12-0tetradecanoylphorbol-13-acetate (TPA), a poten...

OBJECTIVE To study the effectiveness and tolerance of an antiretroviral therapy (ART) regimen composed of the antiretroviral agents (ARVs) stavudine (d4T) plus didanosine (ddI) plus efavirenz (EFV) in patients with advanced HIV infection in Senegal. DESIGN AND METHODS This was an open-label, single-arm, 18-month trial in treatment-naive patients. The primary virologic end point was the percen...

Let m12, m13, . . . , mn−1,n be the slopes of the ( n 2 ) lines connecting n points in general position in the plane. The ideal In of all algebraic relations among the mij defines a configuration space called the slope variety of the complete graph. We prove that In is reduced and Cohen-Macaulay, give an explicit Gröbner basis for it, and compute its Hilbert series combinatorially. We proceed c...

A circular linkage map of the Rhizobium meliloti megaplasmid pRmeSU47b was constructed. The map consists of transposon insertions carrying alternating antibiotic resistance markers linked by phi M12 transduction. Data from conjugation experiments utilizing donor strains carrying Tn5-oriT insertions in the megaplasmid supported the proposed genetic map. In addition, the positions of previously i...

We provide new rationales for corporate venturing (CV), based on competition for talented managers. As returns to venturing increase, …rms engage in CV for reasons other than capturing these returns. First, higher venturing returns increase managerial compensation, to which …rms respond by increasing the power of incentives. Managers increase e¤ort, prompting …rms to reallocate them to new vent...

The Impact of Wage Increases on Job Satisfaction – Empirical Evidence and Theoretical Implications The impact of wage increases on job satisfaction are explored. First, it is empirically established that current job satisfaction rises with absolute wage level as well as with wage increases. Second, a basic job satisfaction function is constructed based on the empirical results, and theoretical ...

This paper explores the consequences of sabotage for the design of incentive contracts. The possibility of sabotage gives rise to a dynamic concern, similar to the Ratchet effect, which distorts the agents’ incentives. We first show that the mere possibility of sabotage may make it impossible to implement the first-best effort, and then offer two distinct incentive schemes, fast track and late ...

Job Assignments under Moral Hazard: The Peter Principle Revisited The Peter Principle captures two stylized facts about hierarchies: first, promotions often place employees into jobs for which they are less well suited than for that previously held. Second, demotions are extremely rare. Why do organizations not correct ‘wrong’ promotion decision? This paper shows in a complete contracting setti...