the core spliceosome? How is RBM15’s association with specific genes regulated? What is the dominant-negative mechanism by which Mpl-TR acts to decrease HSC maintenance? Answers to these questions not only will elucidate critical aspects of the splicing machinery, but will be relevant for our understanding of the role of the RBM15-MKL1 fusion protein in AMKL. Conflict-of-interest disclosure: Th...

A variety of secreted components have been identified as retrograde signals mediating diverse aspects of synaptic development, maintenance, and plasticity; however, little is known about the mechanisms mediating the release of secreted retrograde signals. Doi and Iwasaki (this issue of Neuron) implicate AEX-1, a protein distantly related to the UNC-13/Munc13 family, as an attractive candidate r...

16 Introduction Lubrication is a vital component of machinery and, as with any component, early detection of wear is essential for timely replacement, avoiding unnecessary maintenance while reducing the risk of catastrophic breakdowns. Oil inevitably degrades with use and is exposed to various sources of contamination, both internal and external, which can lead to its degradation and reduced ef...

Condition based maintenance (CBM) seeks to generate a design for a new ship wide CMB system that performs diagnoses and failure prediction on Navy shipboard machinery. Eventually, a variety of shipboard systems will be instrumented with embedded high-performance processors to monitor equipment performance, diagnosis failures, and predict anticipated failures. To illustrate the general principle...

ugmented reality (AR) systems allow A users to interact with real and computergenerated objects by displaying 3D virtual objects registered in a user’s natural environment. Applications of this powerful visualization tool include previewing proposed buildings in their natural settings, interacting with complex machinery for purposes of construction or maintenance and visualizing in-patient medi...

For a long time, it has been understood that neurogenesis is linked to proliferation and thus to the cell cycle. Recently, the gears that mediate this linkage have become accessible to molecular investigation. This review describes some of the progress that has been made in understanding how the molecular machinery of the cell cycle is used in the processes of size regulation in the brain, hist...

Capitalization and sharing of lessons learned play an essential role in managing the activities of industrial systems. This is particularly the case for the maintenance management, especially for distributed systems often associated with collaborative decision-making systems. Our contribution focuses on the formalization of the expert knowledge required for maintenance actors that will easily e...

the core spliceosome? How is RBM15’s association with specific genes regulated? What is the dominant-negative mechanism by which Mpl-TR acts to decrease HSC maintenance? Answers to these questions not only will elucidate critical aspects of the splicing machinery, but will be relevant for our understanding of the role of the RBM15-MKL1 fusion protein in AMKL. Conflict-of-interest disclosure: Th...

The main machinery responsible for cellular protein maintenance is the ubiquitin-proteasomal system, with its core particle the 20S proteasome. The main task of the system is a fast and efficient degradation of proteins not needed anymore in cellular metabolism. For this aim a complex system of regulators evolved, modifying the function of the 20S core proteasome. Here we summarize shortly the ...

The choice of future shipboard power system and the associated zonal electrical distribution system (ZEDS) will have a fundamental impact on the literal shape and configuration of future naval architectures. We propose, during a new phase of ESRDC work, to continue our development and study of ZEDS, and condition based maintenance and control techniques through ZEDS. We also propose to explore ...