In the frame of the development of the DIAMEX process, first studies including counter-current hot tests were performed, with the DiMethyl-DiButylTetraDecylMAlonamide as reference extractant. In parallel, the diamide formula has been optimised so that a new extractant was proposed: the DiMethylDiOctylHexylEthoxyMAlonamide. This new reference extractant was used in two inactive flowsheets. The p...

Macrocyclic heterobinuclear Zn(II)–Cu(II) complexes with phenol based dicompartmental ligands possessing contiguous hexa- and penta-coordination sites were prepared by a stepwise procedure. The ligands include similar N4O2 and dissimilar N(imine)3O2 and N(amine)3O2 coordination sites sharing two phenolic oxygen atoms. The six-coordination site comprises two pyridyl pendant arms on the amine nit...

Abstract This work evaluates the in vitro antioxidant and antidiabetic activities of two metformin hydrochloride-based Schiff bases. Moreover, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay was used to examine cytotoxic effects HL1 HL2 on A549 lung cancer cell line. The bases that have been previously synthesized by using effective, green techniques, namely stirring m...

A resting culture of Rhizopus arrhizus (ATCC 11145) transformed verrucarin A into 16-hydroxyverrucarin A, whereas R. arrhizus transformed verrucarin B into a mixture of 16-hydroxyverrucarin B and 3'-hydroxyverrucarin A. Relative to verrucarins A and B, the 16-hydroxy derivatives showed marked increases in activity, as tested in vivo against P388 mouse leukemia.

In this study, we examined the antitumor activities of isoprenoid derivatives conjugated with substrates of energy metabolism in human hepatoma-bearing athymic mice. Among these compounds, N-geranylpyruvic amide, N-geranyl-p-pyruvaminobenzoic amide, N,N'-digeranylmalic diamide and N,N'-digeranyl-O-acetylmalic diamide had strong antitumor effects. These geranylamine derivatives also inhibited in...

A polycatenated HOF has been constructed from supramolecular embraced pairs of macrocyclic modules, featuring fluorescent detection nitrobenzene in water.

A modular synthetic approach was developed in which variation of the triplets of building blocks used enabled systematic variation of the macrocyclic scaffolds prepared. The approach was demonstrated in the synthesis of 17 diverse natural product-like macrocyclic scaffolds of varied (12-20-membered) ring size. The biological relevance of the chemical space explored was demonstrated through the ...