Inflammatory bowel diseases (IBDs) are a group of chronic, relapsing, immune-mediated disorders of the intestine, including Crohn's disease and ulcerative colitis. Recent studies underscore the importance of the damaged epithelial barrier and the dysregulated innate immune system in their pathogenesis. Metallothioneins (MTs) are a family of small proteins with a high and conserved cysteine cont...

A hybrid sliding level Taguchi-based particle swarm optimization (HSLTPSO) algorithm is proposed for solving multi-objective flowshop scheduling problems (FSPs). The proposed HSLTPSO integrates particle swarm optimization, sliding level Taguchi-based crossover, and elitist preservation strategy. The novel contribution of the proposed HSLTPSO is the use of a PSO to explore the optimal feasible r...

The research into multi-product production/inventory control systems has mainly assumed one of the two strategies: Make-to-Order (MTO) or Make-to-Stock (MTS). In practice, however, many companies cater to an increasing variety of products with varying logistical demands (e.g. short due dates, specific products) and production characteristics (e.g. capacity usage, setup) to different market segm...

In plants, actin filaments have an important role in organelle movement and cytoplasmic streaming. Otherwise microtubules (MTs) have a role in restricting organelles to specific areas of the cell and in maintaining organelle morphology. In somatic plant cells, MTs also participate in cell division and morphogenesis, allowing cells to take their definitive shape in order to perform specific func...

Component-based development i s a n emerging discipline of software development. Recently, the growth of middleware technologies brings the notion of serverside component into CBD f o r developing missioncritical applications. In this paper, we propose the method f o r designing reliable component systems for mission-critical tasks. To this end, we formulate the MTS system and develop the frame...

Cognitive radio (CR) engines often contain multiple system parameters that require careful tuning to obtain favorable overall performance. This aspect is a crucial element in the design cycle yet is often addressed with ad hoc methods. Efficient methodologies are required in order to make the best use of limited manpower, resources, and time. Statistical methods for approaching parameter tuning...

BACKGROUND The German Version of the Manchester Triage System (MTS) has found widespread use in EDs across German-speaking Europe. Studies about the quality criteria validity and reliability of the MTS currently only exist for the English-language version. Most importantly, the content of the German version differs from the English version with respect to presentation diagrams and change indica...

The classification of high dimensional data with kernel methods is considered in this article. Exploiting the emptiness property of high dimensional spaces, a kernel based on the Mahalanobis distance is proposed. The computation of the Mahalanobis distance requires the inversion of a covariance matrix. In high dimensional spaces, the estimated covariance matrix is ill-conditioned and its invers...

Modal Transition Systems (MTSs) provide an appropriate framework for modelling software behaviour when only a partial specification is available. A key characteristic of an MTS is that it explicitly models events that a system is required to provide and is proscribed from exhibiting, and those for which no specification is available, called maybe events. Incremental elaboration of maybe events ...