An amelanotic malignant melanoma is characterized by little or no pigment. It is frequently misdiagnosed because it is a rare entity in general, and because of its unusual clinical features. Liposarcoma is one of the most common adult soft tissue sarcomas. We encountered a case of amelanotic melanoma with a concurrent liposarcoma. A 68-year-old man presented with a single, 1.5x1.5 cm round eryt...

The ionotropic glutamate receptors (N-methyl-D-aspartate receptors (NMDARs)) are composed of large complexes of multi-protein subunits creating ion channels in the cell plasma membranes that allow for influx or efflux of mono- or divalent cations (e.g., Ca(2+)) important for synaptic transmissions, cellular migration, and survival. Recently, we discovered the high prevalence of somatic mutation...

Mature cystic teratoma is the most common germ cell tumor of ovary comprising 10-20% of all ovarian tumors (1). Mature cystic teratoma is generally a benign tumor, however cases of malignant transformation occurs in 1-2% of cases (2). Preoperative diagnosis of malignant transformation is difficult because of the lack of specific symptoms and signs to suggest malignancy.The various types of mali...

Neurofibromatosis is a systemic hereditary disorder with varied manifestations in bone, soft tissue, the nervous system and skin. Cutaneous manifestations of neurofibromatosis are characterized by café-au-lait macules, multiple neurofibromas, Lisch nodules and intertriginous freckling. Some benign or malignant tumors such as juvenile xanthogranuloma, pheochromocytoma, and malignant melanoma can...

The aim of the present study was to investigate the clinical diagnosis and treatment of intracranial malignant melanoma. For this purpose, the clinical manifestation, signs, cerebrospinal fluid (CSF) contents, imageology, pathological features, treatment and prognosis of 7 cases of intracranial malignant melanoma were analyzed in The Chinese PLA General Hospital (Beijing, China) from 1996 to 20...

The malignant transformation of a cystic teratoma is a rare event, occurring in about 0.2% to 1.8%. Primary malignant melanoma arising from the ovary is extremely rare. A primary melanoma in an ovarian cystic teratoma originates most frequently at the dermoepidermal junction, similar to a cutaneous melanoma. Though there are no standard adjuvant regimens for the treatment of primary malignant m...

Malignant skin cancers are the most dreadful human neoplasms that pose severe medical and social problems to healthcare sector globally. Skin tumors broadly classified into two major categories namely; melanoma non-melanoma cancer (NMSC).

Desmoplastic melanoma(DM) is a subtype of malignant melanoma, and there are very few reports on the occurrence this disease in oral region. Since DM mainly composed achromatic spindleshaped tumor cells, its clinical histopathological diagnoses difficult. However, immunohistochemical staining useful for diagnosis DM.