collagen fibrils, extracellular empty spaces(likelyclefts formedfromlipid removalduringprocessing), andpersistentlyactivatedkeratocytesaresimilar to these animal findings. The extracellular lipid collections, which likelycorrespondtothecrystallinedeposits seen clinically, probably arise fromchronicmechanical irritation to keratocytes that continually strive to heal the stromal wound. The breaks...

Methyleugenol (MEG) was tested for toxicity/carcinogenicity in a 2-yr carcinogenesis bioassay because of its widespread use in a variety of foods, beverages, and cosmetics as well as its structural resemblance to the known carcinogen safrole. F344/N rats and B6C3F(1) mice (50 animals/sex/dose group) were given MEG suspended in 0.5% methylcellulose by gavage at doses of 37, 75, or 150 mg/kg/day ...

It has been suggested that there are structurally distinct 'type A' and 'type B' ducts in human nipple. If so, properties such as their relative numbers, accessibility at the nipple surface, and relationships with the breast lobes they communicate with could have biological significance and practical relevance for the intraductal approach to breast cancer diagnosis and treatment. To investigate...

BACKGROUND AND PURPOSE Intracranial artery dolichoectasia (IADE) and coronary artery ectasia have been associated with stroke and myocardial infarction, respectively. Only rarely have cases of coexisting IADE and coronary artery ectasia been reported. We investigated this association in a large consecutive autopsy series. METHODS Sixteen stroke patients with IADE were identified among 381 str...

PURPOSE Four cases of corneal ectasia after small-incision lenticule extraction (SMILE) have been reported. In this review, we provide an overview of the published literature on corneal ectasia after SMILE and risk factors associated with this complication. METHODS Case reports were identified by a search of seven electronic databases for pertinent heading terms between 2011 and July 2017. We...

To date, the laboratory has cloned seven unique human sulfotransferases; five aryl sulfotransferases (HAST1, HAST2, HAST3, HAST4 and HAST4v), an estrogen sulfotransferase and a dehydroepiandrosterone sulfotransferase. The cellular distribution of human aryl sulfotransferases in human hepatic and extrahepatic tissues has been determined using the techniques of hybridization histochemistry and im...

PURPOSE To report a case of corneal ectasia secondary to pars planitis corneal endotheliopathy METHODS Clinical case description and proposed hypothesis regarding development of corneal ectasia RESULTS Eight-year-old male presented with 360° peripheral corneal endotheliopathy and edema, granulomatous keratic precipitates, and mild iritis OD. A progressive corneal ectasia then developed. Twe...

BACKGROUND The purpose of this study was to evaluate the long-term postoperative incidence of and key factors in the genesis of corneal ectasia after myopic laser-assisted in situ keratomileusis (LASIK) in a large number of cases. METHODS A retrospective review of one surgeon's myopic LASIK database was performed. Patients were stratified into two groups based on date of surgery, ie, group 1 ...

Granulomatous lobular mastitis is an unusual breast benign inflammatory disorder with unknown aetiology. It is generally emerged with the clinical symptoms of breast mass, abscess, inflammation and mammary duct fistula. The diagnosis is made by histopathology with a chronic non-necrotizing granulomatous inflammation in lobules of the breast tissue as the microscopic feature. Therapy of granulom...

The first aspect of chronic pancreatitis (CP) is the early phase of relapsing pancreatitis (RP) in which episodes of mild acute pancreatitis (MAP) or severe acute pancreatitis (SAP) occur repeatedly over a period of time [1, 2]. In RP modifications occur mainly at the ductal structures. These can be functional (altered response to secretin administration, late discharge of pancreatic juices int...