N-(3-hydroxy-1, 3, 5 (10) estratrien-17beta-yl)-3-hydroxypropylamine (17β aminoestrogen, prolame) is a steroidal compound with weak estrogen-related trophic-proliferative effects in uterus. Contrasting with 17β-estradiol (E2) pro-coagulant effects, this compound has high anticoagulant and antiplatelet effects. It has been extensively demonstrated that E2 plays important roles in brain function....

BACKGROUND & OBJECTIVES Though newer antiepileptic drugs are considered safer than conventional antiepileptics, the effects of lamotrigine, levetiracetam and topiramate on neurobehavioural functions are yet to be established. This study evaluated neurobehavioural parameters and oxidative stress markers in brain tissue of rats treated with lamotrigine, levetiracetam and topiramate compared to so...

BACKGROUND Methylphenidate (MPH) is a neural stimulant agent, which its neurochemical and behavioral effect remain unclear. Venlafaxine is a serotonin-norepinephrine reuptake inhibitor antidepressant, which was used for management of depression and anxiety. In this study, protective effects of venlafaxine on MPH induced anxiety, depression and cognition impairment were investigated. METHODS F...

Diabetes mellitus is one of the most common causes of neuropathy. Although antioxidant and antidiabetic effects of the aqueous extract of purslane (Portulaca oleracea) (AEOP) have been demonstrated before by other researchers, we did not find any study that assessed the psychobiological effects of AEOP in diabetes induced animals. Thirty ovariectomized (OVX) female Wistar rats were randomly div...

Prenatal Restraint Stress (PRS) in rats is a validated model of early stress resulting in permanent behavioral and neurobiological outcomes. Although sexual dimorphism in the effects of PRS has been hypothesized for more than 30 years, few studies in this long period have directly addressed the issue. Our group has uncovered a pronounced gender difference in the effects of PRS (stress delivered...

Memory disorders are the progressive neurological disorder, mainly causing dementia, memory loss and cognitive dysfunctions. The current study is aimed to experimentally validate crude extract of Canna indica aerial parts (CIA) root (CIR) against aluminium chloride induced altered in rats. Initially, methanolic CIA, hydroalcoholic CIR, their combination CIA + CIR were screened for Invitro antio...

background anxiety is a physiological state characterized by cognitive, somatic, emotional, and behavioral components. there is some evidence in traditional medicine for the effectiveness of lettuce (lactuca sativa) in the treatment of anxiety in humans. objectives the present study investigated the effects of a hydro-alcoholic extract of lettuce on rat behavior in the elevated plus-maze (epm) ...

Uncoupling protein-2 (UCP2) reduces oxidative stress by facilitating the influx of protons into mitochondrial matrix, thus dissociating mitochondrial oxidation from ATP synthesis. UCP2 is expressed abundantly in brain areas and plays a key role in neuroprotection. Here, we sought to determine if UCP2 deficiency produces cognitive impairment and anxiety in young mice, and to determine if hippoca...

Beta-carotene (BC) is a precursor of vitamin A and an excellent antioxidant. It protects the vascular system. Vascular dementia (VaD) one aging disorders causing memory dysfunction. The available medicines for management VaD are limited. present study aimed to evaluate ameliorative effect BC in streptozotocin (STZ)-induced diabetic rats. Diabetic was induced through administration nicotinamide ...

diabetes mellitus is one of the most common causes of neuropathy. although antioxidant and antidiabetic effects of the aqueous extract of purslane (portulaca oleracea) (aeop) have been demonstrated before by other researchers, we did not find any study that assessed the psychobiological effects of aeop in diabetes induced animals. thirty ovariectomized (ovx) female wistar rats were randomly div...