Estrogens stimulate the proliferation of many breast tumors and cell lines derived from them. Antiestrogens have therefore become a powerful therapeutic agent to treat breast tumors that express estrogen receptor (ER) a. In addition, aromatase inhibitors are now used in postmenopausal women to block the in situ conversion of adrenal androgens to estrogens. This approach can only be successful i...

PURPOSE Natural products have been investigated for promising new leads in pharmaceutical development. The purpose of this study was to analyze the biological effect of GE132+Natural, a novel supplement consisting of 5 compounds: Resveratrol, Ganoderma lucidum, Sulforaphane, Lycopene and Royal jelly. METHODS The antiproliferative activity of GE132+Natural was tested on 3 different human cance...

Translationally controlled tumor protein (TCTP) is an evolutionally highly conserved protein which has been implicated in many cellular functions that are related to cell growth, death and tumorigenesis. We used a DNA vector-based RNA interference approach by expressing shRNA to knockdown TCTP in MCF7 cells for evaluating its antitumor effect and its molecular mechanism. TCTP shRNA treatment MC...

Bis(4-fluorobenzyl)trisulfide (BFBTS) is a synthetic molecule derived from a bioactive natural product, dibenzyltrisulfide, found in a subtropical shrub, Petiveria allieacea. BFBTS has potent anticancer activities to a broad spectrum of tumor cell lines with IC50 values from high nanomolar to low micromolar and showed equal anticancer potency between tumor cell lines overexpressing multidrug-re...

the anti-cancer activity of metal ions in the lanthanide group is being considered recently. it has been reported that cerium salts might stimulate the metabolism and therefore, produce anti-cancer effects. however, little is known about the effects of protein-cerium complex in controlling cancer cell growth. the aim of the present study was to elucidate the possible pathways for the cytotoxic ...

Curcumin (CUR) is the active curcuminoid with many physiological, biochemical, and pharmacological properties. Solubility and stability of CUR is the limiting factors for realizing its therapeutic potential. Bovine β-casein is an abundant milk protein that is highly amphiphilic and self-assembles into stable micellar nanoparticles in aqueous solution. β-Casein nanoparticle can solubilize CUR mo...