Several lines of evidence have suggested a role of the GH/IGF-I axis in the regulation of hemochrome. Many studies have been carried out in GH deficient children and adults about this topic, reporting predominantly a positive effect of recombinant human GH (rhGH) on red series, with no action on serum leucocytes and platelets counts. The aim of this study was to assess the impact of GH deficien...

BACKGROUND Dipyrone (MET, metamizole) is a non-steroidal anti-inflammatory drug commonly used both in human and in veterinary medicine. After oral administration, is broken down rapidly to metabolites which largely retain the activity of the parent drug. Its metabolites have analgesic, antipyretic and anti-inflammatory effects. RESULTS The subjects were eight healthy male Large White post-suc...

Increased hemoglobin A(2) (HbA(2); ie, levels > 3.9%) is the most important feature of β-thalassemia carriers. However, it is not uncommon to find persons with borderline HbA(2) (levels, 3.3%-3.8%), who pose a relevant screening problem. Several genotypes have been associated with borderline HbA(2), but sometimes the reasons for this unusual phenotype are unknown. In this paper, we report, for ...

BACKGROUND Beta thalassemia is a preventable disease. Iran has about 20,000Patients who are homozygote for β-thalassaemia and 3,750,000 carriers. The aim of this study was to determine the prevalence of beta thalassemia minor among men who underwent premarital screening in Quchana city in Khorasan Razavi region of Iran. MATERIALS AND METHODS This research is a descriptive cross-sectional stud...

Fetal hemoglobin (HbF) is a recognized modulator of sickle cell disease (SCD) severity. HbF levels are strongly influenced by genetic variants at three major genetic loci, Xmn1-HBG2, HMIP-2, and BCL11A, but the effect of these loci on the hematological phenotype in SCD, has so far not been investigated. In a cohort of individuals with SCD in Tanzania (HbSS and HbS/β° thalassemia, n = 726, aged ...

Natural deletions of the region upstream of the human -globin gene cluster, together with expression studies in cell lines and transgenic mice, identified a single element (HS 40) as necessary and perhaps sufficient for high-level expression of the -globin genes. A similar element occupies the corresponding position upstream of the mouse (m) -globin genes (mHS 26) and was thought to have simila...

objective data on the relationship between iron deficiency anemia and febrile convulsions are controversial. the aim of this study was to determine the association between iron deficiency anemia and febrile convulsions among children. materials & methods this case-control study was conducted during 2006-2007, on 90 children with febrile seizures (case) and 90 febrile children without seizures (...

Normal physiological values of different blood parameters for various animals are influenced by a number of factors such as age, sex, breed, season, altitude, climatic conditions, nutrition and life habits of the species [4,6,9,19]. It has been reported that the significant differences (p < 0.001) in glucose, total lipid, cholesterol, total protein, uric acid and calcium levels were found betwe...