In this study we lyophilized three types of live attenuated polioviruses (Sabin vaccine strains) and evaluated the lyophilized vaccine viruses' heat stability. The virus titers were measured after heating at 37 and 45 and then compared with the titers of conventional liquid vaccine viruses similarly treated. The results showed that lyophilization, while slightly reducing vaccine virus titers,...

Haemagglutination of bluetongue virus (BTV) was demonstrated for the first time by making use of a purified preparation of the virus. The reaction was found to be independent of variations in the pH, temperature, buffer system and origin of the erythrocytes used in the test. A haemagglutination inhibition test, subsequently developed, was demonstrated to be serotype specific. The storage of the...

The characterization of the microstructures of freeze-dried food products determines the speed of and the properties after rehydration. The pore size distribution is an important characteristic of such textures. Spatial homogeneity and the orientation of voids and cracks inside the samples are studied.

Citation: Haggag YA and Faheem AM (2015) Evaluation of nano spray drying as a method for drying and formulation of therapeutic peptides and proteins. The high sensitivity of peptides and proteins to physicochemical stresses during processing and storage is the major hurdle against its pharmaceutical applications. Peptide-based drug formulations are commonly prepared as solid dosage forms becaus...

In 1890 Alt man dried pieces of frozen tissue by placing ¡hem in a vacuum desiccator at —20 °C. Since then the freeze drying technique has been constantly improved. In ¡939 the freeze drying process was placed for the first time on an engineering basis, and 1940 saw the large-scale production of dried plasma for wartime use. The first book unfreeze drying by Flosdorfin 1949 was followed by the ...

Abstract Bacterial nanocellulose (BNC) is a promising material for the use in medical implants. BNC does not induce unwanted reactions vivo , long term stable and possesses unique mechanical properties. However, to make most of these features, must be carefully processed. Details cultivation post-synthetic methods offer various ways control properties BNC. The focus this work put on drying Diff...

Cold pressed peel oil was added to high quality 50°Brix commercial orange concentrate and foam-mat dried, or diluted to single strength juice and freeze-dried using different platen temperatures. Amounts of peel oil ranged from 0.026% to 0.106% for samples to be foam-mat dried, and from 0.011% to 0.109% for freeze drying. For foam-mat drying, previously de veloped standard commercial conditions...

The possibility to fabricate marine collagen porous structures crosslinked with genipin under high pressure carbon dioxide is investigated. Collagen from shark skin is used to prepare pre-scaffolds by freeze-drying. The poor stability of the structures and low mechanical properties require crosslinking of the structures. Under dense CO2 atmosphere, crosslinking of collagen pre-scaffolds is allo...

Orodispersible tablets, usually prepared using freeze-drying method, are becoming a popular drug formulation for patients who have difficulties swallowing solid dosage forms. The influence of drug solubility and concentration on the physical characteristics of lyophilized tablets composed of mannitol and gelatin was investigated. Phenobarbital and phenobarbital sodium were studied as model drug...

Staphylococcus aureus phage ISP was lyophilized, using an Amsco-Finn Aqua GT4 freeze dryer, in the presence of six different stabilizers at different concentrations. Stability of the lyophilized phage at 4 °C was monitored up to 37 months and compared to stability in Luria Bertani broth and physiological saline at 4 °C. Sucrose and trehalose were shown to be the best stabilizing additives, caus...