OBJECTIVE Both excessive and insufficient activation of WNT signalling results in cartilage breakdown and osteoarthritis. WNT16 is upregulated in the articular cartilage following injury and in osteoarthritis. Here, we investigate the function of WNT16 in osteoarthritis and the downstream molecular mechanisms. METHODS Osteoarthritis was induced by destabilisation of the medial meniscus in wil...

BACKGROUND The aim of this study was to document the development of bilateral knee osteoarthritis over a 12 year period using a middle-aged population-based cohort with knee pain at inclusion. METHODS One hundred and forty three patients aged 35 to 54 were recruited from a population based cohort of 279 subjects who had knee pain at baseline and assessed with clinical and radiographic data, w...

This study examined the influence of a 6-week gait retraining program on the knee adduction moment (KAM) and knee pain and function. Ten subjects with medial compartment knee osteoarthritis and self-reported knee pain participated in weekly gait retraining sessions over 6 weeks. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores and a 10-point visual-analog pain scale...

PURPOSE To compare the outcome of bicompartmental knee arthroplasty (BKA) versus total knee arthroplasty (TKA) in patients with medial and patellofemoral knee osteoarthritis. METHODS Records of 17 women and 10 men with medial and patellofemoral osteoarthritis of the knee who underwent BKA (n=15) or TKA (n=12) were reviewed. All surgeries were performed by the same surgeon. Patient haemoglobin...

Osteoarthritis in the setting of varus deformity can be difficult to treat in young and middle aged patients. Treatment options typically include arthroplasty versus joint preservation techniques. In young and middle aged patients, unicompartmental or total knee arthroplasty is often considered a less desirable treatment option due to the increased likelihood of requiring revision arthroplasty ...

n engl j med 369;26 nejm.org december 26, 2013 e37 A 65-year-old woman presented with pain in both knees. She had received a diagnosis of osteoarthritis of the knee previously and had been treated with analgesic agents and nonsteroidal antiinflammatory drugs. In addition, she was treated intermittently with intraarticular injection of a glucocorticoid. In spite of these therapies, the arthralgi...

PURPOSE Primary total knee arthroplasty (TKA) can be an alternative method for treating distal femoral fractures in elderly patients with knee osteoarthritis. The purpose of this study was to evaluate the clinical and radiographic results in patients with knee osteoarthritis who underwent TKA with the Medial Pivot prosthesis for distal femoral fractures. MATERIALS AND METHODS Eight displaced ...

INTRODUCTION: In varus osteoarthritis, patients often present with variable amounts of denuded articular cartilage in the medial compartment. Further, in severe cases, the surgeon will often encounter subchondral bone loss in the distal femur, the medial femoral condyle, and medial tibial plateau, of varying amounts. These osteochondral defects will ultimately lead to varus angulation, and ofte...

Joint diseases, such as osteoarthritis, induce pain and loss of mobility to millions people around the world. Current clinical methods for diagnosis osteoarthritis include X-ray, magnetic resonance imaging, arthroscopy. These may be insensitive earliest signs osteoarthritis. This study investigates a new procedure that was developed validated numerically use in evaluation cartilage quality. fin...