نتایج جستجو برای: mediator domain
تعداد نتایج: 449434 فیلتر نتایج به سال:
BACKGROUND Reduced heart rate variability (HRV), a non-invasive marker of autonomic dysfunction, and an unhealthy lifestyle are associated with an increased morbidity and mortality of cardiovascular diseases (CVD). The autonomic dysfunction is a potential mediator of the association of behavioural risk factors with adverse health outcomes. We studied the association of HRV with behavioural risk...
Transcription factors and cofactors play critical roles in cell growth and differentiation. Alterations of their activities either through genetic mutations or by viral oncoproteins often result in aberrant cell growth and tumorigenesis. The transcriptional cofactor p300 has recently been shown to be complexed with transcription factors YY1 and CREB. Adenovirus E1A oncoproteins target these tra...
In this paper we study the problem of providing controlled access to confidential data stored in semistructured databases. More specifically, we focus on privacy violations via data inferences that occur when domain knowledge is combined with nonprivate data. We propose a formal model, called Privacy Information Flow Model, to represent the information flow and the privacy requirements. These p...
The explosion of the number of web-based information sources has drastically increased the need for intelligent mediation tools to be implemented between the users and these information resources. These tools must overcome the limitations of the current search engines while making it possible for the users to submit more sophisticated queries than simple key words. On the other hand, we can inc...
The PHYTOCHROME AND FLOWERING TIME1 gene encoding the MEDIATOR25 (MED25) subunit of the eukaryotic Mediator complex is a positive regulator of jasmonate (JA)-responsive gene expression in Arabidopsis (Arabidopsis thaliana). Based on the function of the Mediator complex as a bridge between DNA-bound transcriptional activators and the RNA polymerase II complex, MED25 has been hypothesized to func...
The TNF superfamily member homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for herpesvirus entry mediator (HVEM), a receptor expressed by T lymphocytes (LIGHT) [TNF superfamily (SF)-14], is a key cytokine that activates T cells and dendritic cells and is implicated as a mediator of inflammatory, metabolic, and malignant diseases. LIGHT engages the...
Dysregulation of lipid homeostasis is intimately associated with obesity, type 2 diabetes, and cardiovascular diseases. Sterol regulatory-element binding proteins (SREBPs) are the master regulators of lipid biosynthesis. Previous studies have shown that the conserved transcriptional cofactor Mediator complex is critically required for the SREBP transcriptional activity, and recruitment of the M...
In a conventional information mediation scenario it is assumed that all sources, including their schemas, are known before the integrated view is defined. We have found this assumption to be unrealistic for scientific information integration – new relevant sources are discovered quite frequently, and need to be integrated incrementally with an existing federation. In this paper, we address the ...
The RNA polymerase II-associated protein 1 (RPAP1) is conserved across metazoa and required for stem cell differentiation in plants; however, very little is known about its mechanism of action or its role in mammalian cells. Here, we report that RPAP1 is essential for the expression of cell identity genes and for cell viability. Depletion of RPAP1 triggers cell de-differentiation, facilitates r...
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