OBJECTIVES Novel therapeutics are an important part of ophthalmologists' armamentarium, and the risks and benefits of these therapies must be carefully evaluated. We sought to quantify the characteristics of the pivotal clinical trials supporting the regulatory approval of new ophthalmic drugs and medical devices. DESIGN Retrospective observational study. SETTING AND DATA SOURCE Medical rev...

Ophthalmologists are strongly opposed to any move by optometrists to treat anterior segment disease. Or are they? This year the optometric journal Optician has been examining this question by gauging opinions from grassroots professionals and from their representative bodies. At a time when UK universities are oVering optometrists the first postgraduate courses in ocular therapeutics the result...

The expansion of tools against HIV transmission has brought increased interest in epidemiological models that can predict the impact of these interventions. The EMOD-HIV model was recently compared to eleven other independently developed mathematical models of HIV transmission to determine the extent to which they agree about the potential impact of expanded use of antiretroviral therapy in Sou...

Therapy is not simply a domain or form of medical practice, but also a metaphor for and a performance of medicine, of its functions and status, of its distinctive mode of action upon the world. This article examines medical treatment or therapy (in Russian lechenie), as concept and practice, in what came to be known in Russia as defectology (defektologiia) - the discipline and occupation concer...

Ann M. Bailey, Le Zhan, Dipen Maru, Imad Shureiqi, Curtis R. Pickering, Galina Kiriakova, Julie Izzo, Nan He, Caimiao Wei, Veerabhadran Baladandayuthapani, Han Liang, Scott Kopetz, Garth Powis, and Grace L. Guo Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas...

Preclinical development of and research on potential Middle East respiratory syndrome coronavirus (MERS-CoV) medical countermeasures remain preliminary; advancements are needed before most countermeasures are ready to be tested in human clinical trials. Research priorities include standardization of animal models and virus stocks for studying disease pathogenesis and efficacy of medical counter...

Lipoprotein Metabolism and Lipid Management in Chronic Kidney Disease Bonnie C.H. Kwan,* Florian Kronenberg, Srinivasan Beddhu, and Alfred K. Cheung *Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China; Division of Nephrology & Hypertension and Dialysis Program, University of Utah, and Medical Service, Veterans Affairs Salt Lake City Healthcare System, S...

Numerous therapeutics for prevention and treatment of anxiety have been suggested but many people select alternative medicine such as homeopathy. Homeopathy is an old system of medicine which is used as an effective treatment in both acute and chronic medical and psychological conditions. The ''Homeopathy'' term is a Greek word that means similar disease. Homeopathy has a holistic approach to t...

It is rare to find two books published at around the same time and on a similar subject in the history of medicine and to be able to welcome them both with enthusiasm. But John Harley Warner's study of nineteenth-century American practitioners, and Irvine Loudon's account of medical practice in England between 1750-1850, merit such a response. Both deserve a wide readership among historians. Th...