Na+,K+-ATPase was localized at the ultrastructural level in rat and rabbit kidney medulla. The cytochemical method for the K+-dependent phosphatase component of the enzyme, using p-nitrophenylphosphate (NPP) as substrate, was employed to demonstrate the distribution of Na+, K+-ATPase in tissue-chopped sections from kidneys perfusion-fixed with 1% paraformaldehyde-0.25% glutaraldehyde. In other ...

The activity of phenylethanolamine-N-methyl transferase, an enzyme that synthesizes adrenaline from noradrenaline in the adrenal medulla, is markedly depressed following hypophysectomy. Enzyme activity is restored to normal after administration of ACTH or the potent glucocorticoid, dexamethasone. Thus the biosynthesis of adrenaline in the adrenal medulla appears to be regulated by the pituitary...

Experiments were performed to determine the distribution of oestrogen receptors in normal human kidney. Cytosols prepared from renal medulla and cortex were separately analyzed for oestrogen receptor molecules aga gel electrophoresis. Oestrogen receptors could be demonstrated in both compartments of the organ. However, the experiments reveal that the medulla is the main locus of oestrogen recep...

Introduction: Pheochromocytomas are catecholamine-producing neuroendocrine tumors that arise from the adrenal medulla. typically present with uncontrollable or paroxysmal hypertension can be accompanied by other common initial symptoms, including headache, diaphoresis, arrhythmia, and pallor. Given morbidity mortality associated undiagnosed pheochromocytomas, their potential for treatment, prim...

Concerns about inappropriate drug use are increasing in geriatric patients. Potentially medication (PIM) lists being updated accordingly. The aim of this study is to determine the prevalence PIM elderly Turkish hemodialysis patients and assess association patient’s characteristic as risk factors for PIMs population. Patients aged 65 years over who were treated at two different centers included ...

Background and purpose To assess the anatomical distribution of the ischemic strokes of the brainstem, the effect of anatomical distribution on clinical features and prognosis, and the association between etiology and anatomical involvement. Methods A retrospective search of the patient database of our institution was performed for a total of 227 patients who were admitted to the Department o...

We investigated the hypothesis that stimulation of metabotropic excitatory amino acid receptors in the ventrolateral medulla evokes cardiovascular responses. Thus, (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid [(1S,3R)-ACPD], a selective agonist of metabotropic excitatory amino acid receptors, was microinjected into the rostral or caudal ventrolateral medulla of halothane-anesthetized Sprag...

INTRODUCTION Thyroid hormone disorders in patients with chronic kidney disease (CKD) are a result of impaired conversion of T4 to T3. The importance of kidneys in thyroid hormones conversion is not fully understood. The activities of different types of iodothyronine deiodinases in the kidney structures have not been determined yet. The aim of this study was to determine the activity of deiodina...