Subject and Methods Twenty nine children (age range 3 months to 12 years) diagnosed as megaloblastic anemia over a period of three year (March 1993 to March 1996) were prospectively studied. All anemic children admitted with or without bleeding manifestations had their peripheral blood smear examined. Complete hemogram including platelet count and mean corpuscular volume (MCV) were also carried...

T HE PROFOUND alteration in human erythrobbasts in folic acid or vitamm B12 deficiency is manifest to an important degree by the appearance of the interphase nuclear chromatin in the megaloblastic cells. This is reflected in the appearance of the individual chromosomes, and it is generally agreed that the chromosomes of megaloblasts differ in morphologic details from those of normoblasts. Rohrt...

Thiamine-responsive megaloblastic anemia (TRMA) also known as Rogers syndrome is a rare autosomal recessive disorder characterized by anemia, diabetes mellitus, and progressive sensorineural deafness. The disease can be manifested anytime between infancy adolescence, all the cardinal findings may not present at time of diagnosis. main defect lies in active thiamine uptake into cells which distu...