نتایج جستجو برای: membrane degradation
تعداد نتایج: 529888 فیلتر نتایج به سال:
Development of novel small molecules that selectively degrade pathogenic proteins would provide an important advance in targeted therapy. Recently, we have devised a series of hybrid small molecules named SNIPER (specific and nongenetic IAP-dependent protein ERaser) that induces the degradation of target proteins via the ubiquitin-proteasome system. To understand the localization of proteins th...
Quality control and degradation of misfolded proteins are essential processes of all cells. The endoplasmic reticulum (ER) is the entry site of proteins into the secretory pathway in which protein folding occurs and terminally misfolded proteins are recognized and retrotranslocated across the ER membrane into the cytosol. Here, proteins undergo polyubiquitination by one of the membrane-embedded...
When monolayer cultures of neuroblastoma N2a cells were prelabelled with [(3)H]fucose to steady state, and then reincubated in complete medium in the presence of unlabelled 40mm-l-fucose, there was a rapid metabolism of fucosylated cellular macromolecules and the specific radioactivity of the acid-insoluble material decreased by 22% within 2h. After this period of time the remaining radioactive...
The kinetics of synthesis and degradation of the protein constituents of nuclear membranes, endoplasmic reticulum membranes (rough-surfaced microsomes), G o 1 g i apparatus membranes and plasma membranes were determined following a single administration of L-[guanido-14C] arginine by intraperitoneal injection. Membrane protein was determined as the fraction which resists sonication and sequenti...
Work from several laboratories has indicated that many different proteins are subject to endoplasmic reticulum (ER) degradation by a common ER-associated machinery. This machinery includes ER membrane proteins Hrd1p/Der3p and Hrd3p and the ER-associated ubiquitin-conjugating enzymes Ubc7p and Ubc6p. The wide variety of substrates for this degradation pathway has led to the reasonable hypothesis...
Tritiated borohydride reduction of cells treated in situ with galactose oxidase and neuraminidase was used to label externally oriented glycoproteins and glycolipids of the plasma membrane. The tritium was incorporated into galactose and galactosamine residues of both glycoproteins and glycolipids of two rat hepatoma cell types-monolayer H-35 cells and suspension cultures of HTC cells. The glyc...
BACKGROUND AND METHODS Guided bone regeneration (GBR) is a new treatment for bone defects, and the property of membrane is critical to the success of GBR. This study focuses on a novel membrane tube for GBR, which was prepared by a nanocalcium-deficient hydroxyapatite-multi(amino acid) copolymer (n-CDHA-MAC) composite. The biomechanical strength and degradability of this membrane tube under mec...
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