Background and Objectives: Presence of steroid hormone receptors (estrogen and progesterone) in the tumor tissues of various organs correlates with response to therapy and prognosis. Since their role in ovarian cancer is still controversial, in this study we investigated the expression and prognostic value of the estrogen receptor (ER) and progesterone receptors (PR) in ovarian papillary ser...

The existence of hormone receptors on or within neoplastic tissue has potential diagnostic, therapeutic, and prognostic importance. It was the purpose of this study to measure estrogen and progesterone receptors in a large group of patients with head and neck cancer to determine their frequency. Sixty-five patients with head and neck tumors underwent a total of 75 estrogen and 50 progesterone r...

Gliomas are the most common type of primary central nervous system neoplasm. Astrocytomas are the most prevalent type of glioma and these tumors may be influenced by sex steroid hormones. A literature review for the presence of estrogen and progesterone receptors in astrocytomas was conducted in the PubMed database using the following MeSH terms: "estrogen receptor beta" OR "estrogen receptor a...

Classically, the actions of progesterone (P4) are attributed to the binding of nuclear progesterone receptor (PR) and subsequent activation of its downstream target genes. These mechanisms, however, are not applicable to PR- or basal phenotype breast cancer (BPBC) due to lack of PR in these cancers. Recently, the function of membrane progesterone receptor alpha (mPRα) in human BPBC cell lines w...

To obtain drugs which are more selective at benzodiazepine (BZD) receptors, design and synthesis of functionally selective ligands for BZD receptors is the current strategy of our pharmaceutical chemistry department. The affinity of newly synthesized ligands is assessed by radioligand receptor binding assays. Based on our previous studies, 2-phenyl-5-oxo-7-methyl-1,3,4-oxadiazolo[a,2,3]-pyrimid...

We have used a new monoclonal antibody, designated C-262, directed against the last 14 amino acids of the carboxy-terminus of human progesterone receptors (N. L. Weigel et al., Mol. Endocrinol., 6: 1585-1597, 1992) to analyze progesterone receptor structure. This new antibody recognizes the previously described B-receptors (Mr 120,000) and the naturally occurring N-terminal truncated A-receptor...

The metabolism of progesterone bound to uterine nuclear progesterone receptors was accelerated in vitro by incubation at 25°C for 30min with NADPH generator. The characteristics of progesterone metabolites and receptors were examined by 3H-R5020 exchange assay. Progesterone bound nuclei were prepared from uteri of estradiol-primed progesteronetreated ovariectomized rats. The specific nuclear R5...

We have used a new monoclonal antibody, designated C-262, directed against the last 14 amino acids of the carboxy-terminus of human progesterone receptors (N.L. Weigel et al., Mol. Endocrinol., 6: 1585-1597, 1992) to analyze progesterone receptor structure. This new antibody recognizes the previously described B-receptors (M(r) 120,000) and the naturally occurring N-terminal truncated A-recepto...

The mechanism of progesterone inhibition of casein gene expression was analyzed in a two-step culture model of the whole mammary organ of the mouse. Cellular accumulation of casein mRNA (mRNA,.,) was used as a measure of casein gene expression. A specific mouse casein cDNA (cDNA,.,) was used as a hybridization probe to monitor mRN&,,, in the glands. Six days of step I incubation in medium conta...

AIM To make a quantitative evaluation by image analysis of oestrogen receptors, progesterone receptors, and androgen receptors in papillary hidradenomas and anogenital sweat glands. METHODS 20 papillary hidradenomas and the anogenital sweat glands detected in surgical specimens selected from 10 vulvectomies for squamous carcinoma, eight haemorrhoidectomies, and one anal polypectomy, all from ...